Tetradecyltrimethylammonium bromide

Tetradecyltrimethylammonium bromide Basic information
Physical properties
Product Name:Tetradecyltrimethylammonium bromide
Synonyms:alkyl*trimethylammoniumbromide*(c14,5%c16);alkyltrimethylammoniumbromide;alkyltrimethylammoniumbromide(c14,5%c16);tetradecyltrimethyl-ammoniubromide;MYRTRIMONIUM BROMIDE;(1-Tetradecyl)trimethylammonium bromide;TETRADECYLTRIMETHYLAMMONIUM BROMIDE, FOR IPC;MicrocideIitm
CAS:1119-97-7
MF:C17H38N.Br
MW:336.39
EINECS:214-291-9
Product Categories:Pharmaceutical raw materials;Ammonium Bromides (Quaternary);Quaternary Ammonium Compounds;1119-97-7
Mol File:1119-97-7.mol
Tetradecyltrimethylammonium bromide Structure
Tetradecyltrimethylammonium bromide Chemical Properties
Melting point 245-250 °C(lit.)
density 1.1328 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5260 (estimate)
storage temp. Store below +30°C.
solubility H2O: 10 % (w/v)
form Fine Crystalline Powder
color White
PHpH (50g/l, 25℃ : 4.0~6.0
Water Solubility 20 g/100 mL
Sensitive Hygroscopic
λmaxλ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02
Merck 14,6336
BRN 3633227
Stability:Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKeyCXRFDZFCGOPDTD-UHFFFAOYSA-M
LogP2.2 at 20℃
CAS DataBase Reference1119-97-7(CAS DataBase Reference)
EPA Substance Registry SystemTetradecyl trimethyl ammonium bromide (1119-97-7)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45-27
RIDADR UN 3263 8/PG 2
WGK Germany 3
RTECS BS5776000
3
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29239000
ToxicityLD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Tetradecyltrimethylammonium bromide Usage And Synthesis
Physical propertiesCetrimide is a white fine powder crystal with a melting point of 245°C to 250°C. A rough estimate of its density is 1.1328. It is soluble in water with a solubility of 20 g/100 mL.
DescriptionMiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4
UsesMyristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis.
UsesDisinfectant; deodorant; laboratory reagent.
DefinitionMyristyltrimethylammonium bro-mide.
General DescriptionMyristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant.
Purification MethodsCrystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]
References1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425 2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78 3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010 4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609
Tetradecyltrimethylammonium bromide Preparation Products And Raw materials
Raw materialsTrimethylamine-->1-Bromotetradecane
CETRIMIDE NALIDIXIC ACID AGAR CN CETRIMIDE AGAR HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE Methyltrioctadecylammonium bromide CETRIMIDE POWDER MILK AGAR WITH CETRIMIDE triethylhexadecylammonium bromide Dimethylditetradecylammonium bromide CETRIMIDE BROTH CETRIMIDE BROTH FOR MICROBIOLOGY* TETRAHEXADECYLAMMONIUM BROMIDE HEXADECYLTRIMETHYLAMMONIUM BROMIDE-D33 Dihexadecyldimethylammonium bromide Rapacuronium STRONG CETRIMIDE SOLUTION HEXADECYLTRIOCTADECYLAMMONIUM BROMIDE CETYLBENZYLDIMETHYLAMMONIUM BROMIDE CETRIMIDE AGAR PLATES, BOX WITH 30 PLATES

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