Aloin

Aloin Basic information
Product Name:Aloin
Synonyms:barbaloin from aloe barbadensis*miller leaves;Barbaloin std.;BarbaloinStandard;9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-;1,8-dihydroxy-10-(β-d-glucopyranosyl)-3-(hydroxymethyl)-9(10h)-anthracenone;ALOIN A(BARBALOIN)(P);ALOIN A(BARBALOIN)(SH);ALOIN B(P)(NEW)
CAS:1415-73-2
MF:C21H22O9
MW:418.39
EINECS:215-808-0
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Natural Plant Extract;Plant extract;Herb extract
Mol File:1415-73-2.mol
Aloin Structure
Aloin Chemical Properties
Melting point 148°C
Boiling point 456.17°C (rough estimate)
density 1.3028 (rough estimate)
refractive index 1.6230 (estimate)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility pyridine: 50 mg/mL, clear, dark red
form neat
pka7.12±0.40(Predicted)
color Yellow needles from EtOH
BRN 6077558
Stability:Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible.
InChIKeyAFHJQYHRLPMKHU-WEZNYRQKSA-N
LogP0.944 (est)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS LZ6520000
8
HS Code 29329990
ToxicityLDLo orl-cat: 500 mg/kg HBAMAK 4,1298,35
Aloin Usage And Synthesis
Chemical Propertieslemon yellow crystalline powder
UsesAloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Recent studies have investigated Aloin as an ant ineoplastic agent that enhances melanogenesis and transglutaminase activity.
UsesAloe exudant, used as a stimulant-laxative
DefinitionChEBI: A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S d astereoisomer).
Safety ProfilePoison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits acrid smoke and fumes.A carthartic and purgative.
Purification MethodsAloin forms the monohydrate as lemon yellow crystals on crystallisation from H2O (450g/1.5L) which has a lower m ~70-80o than the anhydrous substance. [Cahn & Simonsen J Chem Soc 2573 1932, Hay & Haynes J Chem Soc 3141 1956.]
Aloin Preparation Products And Raw materials
Aloe emodin 1,1-DIPHENYLHEXANE Solvent Red 43 3,3-Diphenylpropanol ALOIN,POWDER,ALOIN, CRUDE Emodin Emodin-3-methyl ether 5-ISOPROPYL-3-METHYLPHENOL 2,5-DIMETHYLPHENETHYL ALCOHOL 1,1-DIPHENYL-2-PROPANOL Aloin BARBALOIN(SEE ALOIN A PART# 01625-10)(SH) 2,2'-DIHYDROXYBENZOPHENONE Ellagic acid (R)-(-)-1,1-DIPHENYL-2-PROPANOL Tris(hydroxymethyl)nitromethane Aloin1.5%(3:1) 1,1-DIPHENYLHEPTANE

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