ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Ethyl compound 1-Chloroethyl chloroformate

1-Chloroethyl chloroformate

1-Chloroethyl chloroformate Basic information
Product Name:1-Chloroethyl chloroformate
Synonyms:1-Chloroethyl carbonochloridoate;a-Chloroethoxycarbonyl chloride;1-CHLOROETHYL CHLOROFORMATE, 97+%;1-Chloroethyl chloroformate,Carbonochloridic acid;1-Chlotoethyl chloroformate;Chloroethyl 1-chloroformate;1 - chlorine ethyl chloride acid es;RELU-012
CAS:50893-53-3
MF:C3H4Cl2O2
MW:142.97
EINECS:256-834-2
Product Categories:Acid Halides;Building Blocks;CHLOROFORMATES;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;50893-53-3
Mol File:50893-53-3.mol
1-Chloroethyl chloroformate Structure
1-Chloroethyl chloroformate Chemical Properties
Melting point -65°C
Boiling point 118-119 °C (lit.)
density 1.325 g/mL at 25 °C (lit.)
vapor pressure 3.25 psi ( 20 °C)
refractive index n20/D 1.422(lit.)
Fp 105 °F
storage temp. 2-8°C
solubility Miscible with most organic solvents.
form Liquid
color Clear colorless
Sensitive Moisture Sensitive
BRN 1747601
Stability:Hygroscopic, Moisture Sensitive
InChIKeyQOPVNWQGBQYBBP-UHFFFAOYSA-N
CAS DataBase Reference50893-53-3(CAS DataBase Reference)
NIST Chemistry Reference«ALPHA»-chloroethyl chloroformate(50893-53-3)
Safety Information
Hazard Codes T
Risk Statements 10-22-23-34
Safety Statements 26-36/37/39-45
RIDADR UN 2742 6.1/PG 2
WGK Germany 3
F 10-19-21
TSCA No
HazardClass 6.1
PackingGroup II
HS Code 29159000
MSDS Information
ProviderLanguage
1-Chloroethyl chloroformate English
SigmaAldrich English
ALFA English
1-Chloroethyl chloroformate Usage And Synthesis
Chemical PropertiesClear and colorless liquid
UsesReagent for the selective N-dealkylation of tertiary amines in high yields.
Uses1-Chloroethyl chloroformate was used:
  • for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection
  • as catalyst in chemoselective desilylation of silyl-protected alcohols
  • as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications
  • as reagent to cleave benzhydryl groups from amines
1-Chloroethyl chloroformate Preparation Products And Raw materials
Preparation ProductsCefpodoxime proxetil-->N-Boc-Nortropinone-->Methyl 1-Boc-3-pyrrolidinecarboxylate-->1-Chloroethyl cyclohexyl carbonate-->1-Iodododecane-->1,1-Dichloroethane-->1-chloroethyl propyl carbonate-->Glycine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-, [2-[[(1-chloroethoxy)carbonyl]MethylaMino]-3-pyridinyl]Methyl ester-->1-chloroethyl sulfochloridate
1-CHLORO-2-METHYLPROPYL CHLOROFORMATE b-Chloroethyl chloroformate,2-CHLOROETHYL CHLOROFORMATE Chloromethyl methyl ether Chloromethyl chloroformate Triethyl orthoformate Urethane (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE CHLOROETHANE 1-Chloroethyl chloroformate Diisononyl phthalate Ethyl chloroformate ALPHA-CHLORO-2-(TRIFLUOROMETHYL)BENZYL CHLOROFORMATE Diethyl azodicarboxylate Chloromethyl ethyl ether Methyl chloroformate Benzyl chloroformate BIS(CHLOROMETHYL)ETHER Benzyl benzoate
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