POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER

POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER Basic information
Product Name:POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER
Synonyms:NONOXYNOL-1;NONOXYNOL-100;NONOXYNOL-120;Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)5;Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)7.5;Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)10;Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)15;Polyethylene Glycol Mono-4-nonylphenyl Ether n(=:)18
CAS:26027-38-3
MF:C17H35O4S.Na
MW:0
EINECS:500-045-0
Product Categories:Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols;CONCEPTROL
Mol File:26027-38-3.mol
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER Structure
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER Chemical Properties
Boiling point 30℃
density 1.00
vapor pressure 0Pa at 25℃
refractive index 1.4950-1.4990
Fp >150℃
storage temp. Sealed in dry,Room Temperature
solubility Miscible with water, with ethanol (96 per cent) and with vegetable oils.
form powder to lump to clear liquid
color Almost colorless liquid
Water Solubility 1g/L
Merck 14,6677
InChIKeyHNLXNOZHXNSSPN-UHFFFAOYSA-N
LogP4.48
EPA Substance Registry Systemp-Nonylphenol polyethylene glycol ether (26027-38-3)
Safety Information
RTECS MD0906000
HS Code 2909.49.6000
Hazardous Substances Data26027-38-3(Hazardous Substances Data)
Toxicityotr-mus:fbr 10 ppm CRNGDP 3,553,82
MSDS Information
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER Usage And Synthesis
DescriptionThe general formula of nonoxynols is C9H19C6H4(OCH2CH2)nOH. Each nonoxynol is characterized by the number (n) of ethylene oxide repeated in the chain. They are present in detergents, liquid soaps, emulsifiers for creams, fabric softeners, photo graphie paper additives, hair dyes, lubricating oils, spermicides and anti-infective agents. They are irritants and sensitizers.
Chemical PropertiesClear, colourless or light yellow, viscous liquid.
OriginatorOrtho-Delfen ,Cilag,France,1971
UsesNonoxynol-6 was reported as a sensitizing agent in an industrial hand cleanser and in a crackindicating fluid used in ilie metal industry. Nonoxynol- 9 is most commonly used as a preservative in topical antiseptics or in spermicides. Nonoxynol-10 was reported as a UV-B photosensitizer. Nonoxynol-12 (nonylphenol ethoxylate) caused contact dermatitis in a domestic cleaner who used a polish containing it.
Usesspermatocide, contraceptive
DefinitionChEBI: Tergitol is a poly(ethylene glycol) derivative that is poly(ethylene glycol) in which one of the terminal hydroxy groups has been converted into the corresponding p-nonylphenyl ether. It has a role as a nonionic surfactant. It is a poly(ethylene glycol) derivative and a hydroxypolyether.
Manufacturing Process220 parts of isononylphenol prepared by condensation of phenol with an olefin mixture obtained by polymerization of propylene and containing essentially isononylenes are caused to react with 0.5 part of caustic alkali powder. The whole is heated to about 130°C to 135°C and the water formed is removed under reduced pressure, while stirring. Thereupon, ethylene oxide is introduced into the melt, while well stirring, during which operation care must be taken, that the temperature of the reaction mass is maintained between 180°C and 200°C. When about 300 parts of ethylene oxide are taken up, the reaction is interrupted. A water-soluble oil is obtained.
Brand nameConceptrol (Ortho Pharmaceutical); Emko (Schering-Plough HealthCare); Gynol II (Ortho Pharmaceutical); Intercept (Ortho Pharmaceutical); Semicid (Whitehall-Robins); Today Sponge (Whitehall-Robins).
Therapeutic FunctionSpermatocide (vaginal)
Flammability and ExplosibilityNotclassified
Contact allergensTheir general formula is C9H19C6H4(OCH2CH2)nOH. Each nonoxynol is characterized by the number (n) of ethylene oxide units repeated in the chain; for example, nonoxynol-9, nonoxynol-14. They are present in detergents, liquid soaps, emulsifiers for creams, fabric softeners, photographic paper additives, hair dyes, lubricating oils, spermicides, and antiinfective agents. They are irritants and sensitizers. Nonoxynol-6 was reported as a sensitizing agent in an industrial hand cleanser and in a crack-indicating fluid in the metal industry. Nonoxynol-9 is the most commonly used, as a preservative in topical antiseptics or in spermicides, acting as a iodophor in PVP-iodine solutions. Nonoxynol-10 was reported as a UVB-photosensitizer. Nonoxynol-12 caused contact dermatitis in a domestic cleaner who used a polish containing it.
Safety ProfilePoison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. An active ingredient in contraceptive jelhes, foams, and creams. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.
POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER Preparation Products And Raw materials
Raw materialsSodium hydroxide-->isononylphenol-->ETHYLENE OXIDE
Preparation ProductsNonylphenoxypoly(ethyleneoxy)ethanol
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE 17-SULFATE DIPOTASSIUM SALT SALICYLIC ACID 4-OCTYLPHENYL ESTER Estradiol-3-benzoate-17-butyrate 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL TETRA ACETATE 1,3,5[10]-ESTRATRIENE-3,16ALPHA,17BETA-TRIOL 3-CARBOXYMETHYL ETHER Estradiol diacetate 4-OCTYLPHENYL 2-CHLORO-4-(4-HEPTYLBENZOYL-OXY)BENZOATE 2-(4-NONYLPHENOXY)ACETIC ACID ESTRONE 3-HEMISUCCINATE B-ESTRADIOL 3-CARBOXYMETHYL ETHER 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT Quinestrol 17-BETA-ESTRADIOL 3,17-DIPROPIONATE ESTRIOL 3-BENZYL ETHER ESTRIOL TRIACETATE Estradiol benzoate ESTRONE ACETATE 1,3,5[10]-ESTRATRIENE-3,16ALPHA,17BETA-TRIOL 3-GLUCURONIDE SODIUM SALT

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