|
| | SPLITOMICIN Basic information |
| Product Name: | SPLITOMICIN | | Synonyms: | SPLITOMICIN;1H-Benzo[f]chromen-3(2H)-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Splitomycin;Splitomicin >;Spitomicin;1,2-Dihydro-3H-benzo[f]chromen-3-one | | CAS: | 5690-03-9 | | MF: | C13H10O2 | | MW: | 198.22 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 5690-03-9.mol |  |
| | SPLITOMICIN Chemical Properties |
| Melting point | 73-74.5℃ | | storage temp. | 2-8°C | | solubility | insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO | | form | solid | | color | White to Almost white |
| WGK Germany | 3 | | HS Code | 2932.20.4500 |
| | SPLITOMICIN Usage And Synthesis |
| Uses | Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent. | | Definition | ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins. | | Synthesis Reference(s) | Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027 | | General Description | A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket. | | Biological Activity | Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast. | | Biochem/physiol Actions | Cell permeable: yes | | storage | +4°C |
| | SPLITOMICIN Preparation Products And Raw materials |
|
