6-Aminocaproic acid

6-Aminocaproic acid Basic information
Description References
Product Name:6-Aminocaproic acid
Synonyms:177 J.D.;177j.d.;177jd;6-amino-hexanoicaci;Acepramin;Acepramine;Afibrin;Amikar
CAS:60-32-2
MF:C6H13NO2
MW:131.17
EINECS:200-469-3
Product Categories:omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Organic acids;Amino Acids;Fibrinogen/Thrombin;Pharmaceutical raw materials;AMICAR;bc0001;60-32-2
Mol File:60-32-2.mol
6-Aminocaproic acid Structure
6-Aminocaproic acid Chemical Properties
Melting point 207-209 °C (dec.) (lit.)
Boiling point 242.49°C (rough estimate)
density 1.042 g/cm3
vapor pressure <0.1 hPa (20 °C)
refractive index 1.4870 (estimate)
Fp 207-209°C
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form powder
pka4.373(at 25℃)
color white
OdorOdorless
PH7.0-7.5 (50g/l, H2O, 20℃)
Water Solubility SOLUBLE
Merck 14,432
BRN 906872
InChIKeySLXKOJJOQWFEFD-UHFFFAOYSA-N
LogP0.027 (est)
CAS DataBase Reference60-32-2(CAS DataBase Reference)
NIST Chemistry ReferenceHexanoic acid, 6-amino-(60-32-2)
EPA Substance Registry SystemHexanoic acid, 6-amino- (60-32-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS MO6300000
TSCA Yes
HS Code 29224995
Hazardous Substances Data60-32-2(Hazardous Substances Data)
ToxicityLD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
MSDS Information
ProviderLanguage
6-Aminohexanoic acid English
SigmaAldrich English
ACROS English
ALFA English
6-Aminocaproic acid Usage And Synthesis
Description6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.
Referenceshttps://pubchem.ncbi.nlm.nih.gov/compound/6-aminohexanoic_acid#section=Pharmacology-and-Biochemistry
https://en.wikipedia.org/wiki/Aminocaproic_acid
Chemical Propertieswhite crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform.
OriginatorEpsilon,Roche,W. Germany,1962
UsesEACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Uses6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.
Preparation6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide.
Application6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.
6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect.
DefinitionChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.
Manufacturing Process5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.
Brand nameAmicar (Xanodyne).
Therapeutic FunctionAntifibrinolytic
General Description6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity.
Biochem/physiol ActionsLysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
Mechanism of actionBecause binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.
Safety ProfileModerately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.
SynthesisAminocaproic acid (24.4.1) is synthesized by hydrolyzing |? -caprolactam at high temperature.

Synthesis_60-32-2

Veterinary Drugs and TreatmentsAminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.
AC-LYS-OH H-LYS(ME)-OH HCL Ethyl 2-(Chlorosulfonyl)acetate N-EPSILON-ACETYL-L-LYSINE 6-Acetamidohexanoic acid Ethyl 1-methylpipecolinate AMINOCAPROIC ACID SIGMA REFERENCE*STANDARD 200 MG PE Boc-6-AMinocaproic acid D-Lysine 3-AMINOHEXANOIC ACID AMIDE DL-PIPECOLIC ACID HYDROCHLORIDE L-Norleucine 5-HYDROXY-DL-LYSINE HYDROCHLORIDE DNP-EPSILON-AMINOCAPROIC ACID HYDROCHLORIDE 6-AMINOCAPROIC ACID, (6-AMINOHEXANOIC ACID) LABOTEST-BB LT00451924 N6-Cbz-L-Lysine 6-[(1-oxomethyloctyl)amino]hexanoic acid

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