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| | 16-HEXADECANOLIDE Basic information |
| | 16-HEXADECANOLIDE Chemical Properties |
| Melting point | 34-38 °C(lit.) | | Boiling point | 188 °C / 15mmHg | | density | 0.94 | | refractive index | n20/D1.4680-1.4730 | | Fp | >100°C | | storage temp. | -20°C | | form | neat | | color | Crystals from EtOH | | Odor | musky odor | | Odor Type | musk | | Water Solubility | Insoluble in water. | | BRN | 148631 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | LogP | 7.3 at 20℃ | | CAS DataBase Reference | 109-29-5(CAS DataBase Reference) | | EPA Substance Registry System | Oxacycloheptadecan-2-one (109-29-5) |
| Hazard Codes | Xi | | Risk Statements | 38 | | Safety Statements | 37 | | WGK Germany | 2 | | RTECS | RN9730000 | | TSCA | Yes | | HS Code | 2932.99.9090 | | Toxicity | CYCLOHEXADECANOLIDE ? DIHYDROAMBRETTOLIDE ? 1,16-HEXADECANOLACTONE ? HEXADECANOLIDE ? 16-HYDROXYHEXADECANOIC ACID LACTONE ? JUNIPERIC ACID LACTONE |
| | 16-HEXADECANOLIDE Usage And Synthesis |
| Chemical Properties | colourless to light yellow solid | | Occurrence | Has apparently not been reported to occur in nature. | | Uses | 16-Hexadecanolide is used in the manfacturing of perfumes. It acts as masking agents. | | Uses | 16-Hexadecanolide may be used as a starting reagent in the synthesis of caeliferin A 16:0. | | Definition | ChEBI: 16-Hexadecanolide is a macrolide. | | Preparation | By the persulphuric acid (or other peracid) oxidation of cyclohexadecanone. | | Synthesis Reference(s) | Tetrahedron Letters, 17, p. 3409, 1976 DOI: 10.1016/S0040-4039(00)93057-0 | | Flammability and Explosibility | Notclassified | | Safety Profile | Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. |
| | 16-HEXADECANOLIDE Preparation Products And Raw materials |
| Raw materials | Hexadecanoic acid, 16-hydroxy-, ethyl ester-->Hexadecanoic acid, 16-chloro--->1,18-Dioxacyclotetratriacontane-2,19-dione-->7,8,15,16,23,24-hexaoxatrispiro[5.2.5.2.5.2]tetracosane-->cyclohexadecanone-->IHDA-->methyl 15-hydroxypentadecanoate-->AMBRETTOLIDE-->CYCLOPENTADECANE-->16-Bromohexadecanoic acid-->1,16-HEXADECANEDIOL | | Preparation Products | 16-Bromohexadecanol-->1,16-DIBROMOHEXADECANE-->Oxacycloheptadecane-->METHYL 15-PHENYLPENTADECANOATE-->16-HYDROXYHEXADECANOIC ACID |
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