|
| | Azosemide Basic information |
| Product Name: | Azosemide | | Synonyms: | 2-chloro-5-(1h-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-benzenesulfonamid;2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenyl-sulfanilamid;SK-110;2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide;2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide;2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide;Azosemide Solution, 1000ppm;Azosemide Solution, 100ppm | | CAS: | 27589-33-9 | | MF: | C12H11ClN6O2S2 | | MW: | 370.84 | | EINECS: | 248-549-7 | | Product Categories: | | | Mol File: | 27589-33-9.mol |  |
| | Azosemide Chemical Properties |
| Melting point | 218-221° | | Boiling point | 221°C (rough estimate) | | density | 1.6843 (rough estimate) | | refractive index | 1.6100 (estimate) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 3.58±0.10(Predicted) | | form | Solid | | color | Crystals | | CAS DataBase Reference | 27589-33-9(CAS DataBase Reference) |
| Toxicity | LD50 orl-rat: 2545 mg/kg IYKEDH 18,666,87 |
| | Azosemide Usage And Synthesis |
| Description | Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions. | | Originator | Boehringer Manheim (W. Germany) | | Uses | Diuretic. | | Uses | Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension. | | Definition | ChEBI: A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hyp
rtension. | | Manufacturing Process | The 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrile used as starting material
is obtained by the reaction of 4-chloro-2-fluoro-5-sutfamoyl-benzonitrile with
thenylamine in anhydrous tetrahydrofuran.
Then the 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole (MP 218°
to 221°C, yield 37% of theory) is obtained by the reaction of 4-chloro-5-
sulfamoyl-2-thenylaminobenzonitrite (MP 170° to 174°C) with sodium azide
and ammonium chloride, | | Brand name | LURET | | Therapeutic Function | Diuretic | | Safety Profile | Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. An experimental teratogen. Whenheated to decomposition it emits toxic fumes of Cl-, SOx,and NOx. |
| | Azosemide Preparation Products And Raw materials |
|
