Propyphenazone

Propyphenazone Basic information
Product Name:Propyphenazone
Synonyms:1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on;3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-;4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on;4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline;4-isopropyl-antipyrin
CAS:479-92-5
MF:C14H18N2O
MW:230.31
EINECS:207-539-2
Product Categories:Aromatics;Heterocycles;Active Pharmaceutical Ingredients;API's;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:479-92-5.mol
Propyphenazone Structure
Propyphenazone Chemical Properties
Melting point 102-105°C
Boiling point 372.3°C (rough estimate)
density 1.0371 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
pka1.46±0.65(Predicted)
form neat
color White to Off-White
Water Solubility 743.6g/L(25.35 ºC)
Merck 14,7871
BRN 204533
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference479-92-5(CAS DataBase Reference)
NIST Chemistry ReferencePropyphenazone(479-92-5)
EPA Substance Registry System3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-22
Safety Statements 26-36/37/39
WGK Germany 3
RTECS CD2800000
HS Code 2933.39.9200
MSDS Information
Propyphenazone Usage And Synthesis
DescriptionThis uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.
Chemical Propertiessolid
UsesAnalgesic; antipyretic; anti-inflammatory.
DefinitionChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.
Brand name539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.
World Health Organization (WHO)Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.
ReferencesHartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)
Propyphenazone Preparation Products And Raw materials
Chlorodimethylphenylsilane Pralmorelin Isoproturon DIANTIPYRYLMETHANE N,N-Dimethylformamide Diphenolic acid Poly(dimethylsiloxane) Isoproterenol ETHANE Propyphenazone BP 5-Chlorovaleric acid Dimethyl sulfide Dimethyl fumarate N,N-Dimethylaniline Dimethyl sulfoxide Dimethyl ether Diisopropyl ether Dimethyl carbonate

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