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| | 2-COUMARANONE Chemical Properties |
| Melting point | 49-51 °C(lit.) | | Boiling point | 248-250 °C(lit.) | | density | 1,22 g/cm3 | | vapor pressure | 0.027-0.24Pa at 10-30℃ | | refractive index | 1.4800 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: soluble3.8g/L at 30°C | | form | Crystalline Powder or Crystals | | color | White to yellow-orange | | BRN | 114689 | | InChIKey | ACZGCWSMSTYWDQ-UHFFFAOYSA-N | | LogP | 1.347 | | Surface tension | 63.8mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 553-86-6(CAS DataBase Reference) |
| | 2-COUMARANONE Usage And Synthesis |
| Description | 2-Coumaranone (also named as Isophthalide, 3H-benzofuran-2-one) belongs to a class of organic compounds named as benzofuranones which exhibits mutagenic and carcinogenic activity. 2-Coumaranone has been used to study the effects of coumarins on 7,12-dimethyibenz(a)anthracene induced neoplasia of the rat mammary gland and as probe for detecting enzymes which hydrolyze 2-hydroxybenzofuran structures.
| | Reference | Y. S. Priya, K. Ramachandra Rao, P. V. Chalapathi, M. Satyavani, A. Veeraiah, Vibrational and UV spectroscopic studies of 2-coumaranone by experimental and density functional theory calculations, Journal of Molecular Structure, 2017, vol. 1144, pp. 535-544
| | Chemical Properties | WHITE TO LIGHT YELLOW CRYSTALLINE POWDER | | Uses | 2-Coumaranone has been used to study the effects of coumarins on 7,12-dimethyibenz(a)anthracene induced neoplasia of the rat mammary gland. It was employed as probe for detecting enzymes which hydrolyze 2-hydroxybenzofuran structures. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 47, p. 2491, 1982 DOI: 10.1021/jo00133a055 |
| | 2-COUMARANONE Preparation Products And Raw materials |
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