4-Hydroxy-3-methoxybenzonitrile

4-Hydroxy-3-methoxybenzonitrile Basic information

Product Name:	4-Hydroxy-3-methoxybenzonitrile
Synonyms:	4-Hydroxy-3-methoxyb;4-Cyano-2-methoxyphenol;4-Hydroxy-3-Methoxybenzonitrile, 98% 25GR;4-Hydroxy-3-methoxybenzonitrile,98%;4-HYDROXY-3-METHOXYBENZONITRILE;AKOS B004154;VANILLONITRILE;VANILO NITRILE
CAS:	4421-08-3
MF:	C8H7NO2
MW:	149.15
EINECS:	224-589-0
Product Categories:	Building Blocks;C8 to C9;Anisoles, Alkyloxy Compounds & Phenylacetates;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aromatic Nitriles;Nitriles;Phenols;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	4421-08-3.mol

4-Hydroxy-3-methoxybenzonitrile Chemical Properties

Melting point	85-87 °C (lit.)
Boiling point	270.21°C (rough estimate)
density	1.2517 (rough estimate)
refractive index	1.5320 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	7.84±0.18(Predicted)
form	powder to crystal
color	White to Light yellow to Light orange
LogP	1.551 (est)
CAS DataBase Reference	4421-08-3(CAS DataBase Reference)

Safety Information

MSDS Information

4-Hydroxy-3-methoxybenzonitrile Usage And Synthesis

Chemical Properties	beige crystalline powder
Uses	4-Hydroxy-3-methoxybenzonitrile was used in the synthesis of 1,5-bis(4-cyano-2-methoxyphenoxy)-3-oxapentane.
Synthesis Reference(s)	Journal of the American Chemical Society, 70, p. 2293, 1948 DOI: 10.1021/ja01186a514
General Description	4-Hydroxy-3-methoxybenzonitrile on treatment with sodium perborate yields 4-hydroxy-3-methoxybenzamide.

4-Hydroxy-3-methoxybenzonitrile Preparation Products And Raw materials

Raw materials	(4-CYANO-2-METHOXYPHENOXY)ACETIC ACID-->3-Hydroxy-4-methoxybenzonitrile-->4-IODO-2-METHOXYPHENOL-->3-METHOXY-4-HYDROXY BENZALDEHYDE OXIME-->vanilglycolic acid-->vanillylamin-->4-Bromo-2-methoxyphenol-->Homovanillic acid-->Methyl 3,4-dimethoxybenzoate-->Tosyl cyanide
Preparation Products	3,4-Dihydroxybenzonitrile-->7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline-->UNC0638-->4-CYANO-2-METHOXYBENZALDEHYDE

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