beta-Epoetin

beta-Epoetin Basic information
Product Name:beta-Epoetin
Synonyms:betaEpoetin;beta-Epoetin;epoetin beta;Epoch;Epoetina beta;Epoetina beta [inn-spanish];Epoetin-beta (genetical recombination);Epoetine beta
CAS:122312-54-3
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
beta-Epoetin Structure
beta-Epoetin Chemical Properties
Safety Information
MSDS Information
beta-Epoetin Usage And Synthesis
UsesAnti-anemic; hematinic.
Brand nameMarogen(Chugai Pharmaceutical Co., Ltd., Japan).
Clinical UseAnaemia associated with renal impairment in pre-dialysis and dialysis patients, and in patients receiving cancer chemotherapy
Drug interactionsPotentially hazardous interactions with other drugs Risk of hyperkalaemia with ACE inhibitors and angiotensin-II antagonists.
MetabolismThe metabolic fate of both endogenous and recombinant erythropoietin is poorly understood. Current evidence from studies in animals suggests that hepatic metabolism contributes only minimally to elimination of the intact hormone, but desialylated epoetin (i.e. terminal sialic acid groups removed) appears to undergo substantial hepatic clearance via metabolic pathways and/or binding. Desialylation and/or removal of the oligosaccharide side chains of erythropoietin appear to occur principally in the liver; bone marrow also may have a role in catabolism of the hormone. Elimination of desialylated drug by the kidneys, bone marrow, and spleen also may occur; results of animal studies suggest that proximal renal tubular secretion may be involved in renal elimination.
beta-Epoetin Preparation Products And Raw materials

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