(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Basic information
Product Name:(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
Synonyms:(1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride;α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride;Einecs 262-216-3;KJBONRGCLLBWCJ-UHFFFAOYSA-O;Bufuralol hydrochloride (Ro 3-4787)
CAS:60398-91-6
MF:C16H24ClNO2
MW:297.82026
EINECS:262-216-3
Product Categories:Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:60398-91-6.mol
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Structure
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Chemical Properties
Melting point 143-146 °C
storage temp. 2-8°C
solubility H2O: soluble
form solid
color white to off-white
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Usage And Synthesis
DescriptionBufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.
UsesA β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.
UsesCYP2D6 substrate
Biochem/physiol ActionsBufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
in vitroBufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.
in vivoBufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers.
references[1] fothergill ga, francis rj, hamilton tc, osbond jm, parkes mw. bufuralol, a new beta-adrenoceptor blocking agent. experientia. 1975 nov 15;31(11):1322-3.
[2] pringle, t. h.,francis, r.j.,east, p.b., et al. pharmacodynamic and pharmacokinetic studies on bufuralol in man. br.j.clin.pharmac. 22, 527-534 (1986).
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Preparation Products And Raw materials

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