ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Cyclic carboxylic acids PROTAC Linker 27

PROTAC Linker 27

PROTAC Linker 27 Basic information
Product Name:PROTAC Linker 27
Synonyms:PROTAC Linker 27;Tos-PEG2-NH2;2-(2-aminoethoxy)ethyl 4-methylbenzenesulfonate;Ethanol, 2-(2-aminoethoxy)-, 1-(4-methylbenzenesulfonate)
CAS:1246286-33-8
MF:C11H17NO4S
MW:259.32
EINECS:
Product Categories:peg
Mol File:1246286-33-8.mol
PROTAC Linker 27 Structure
PROTAC Linker 27 Chemical Properties
Boiling point 414.5±30.0 °C(Predicted)
density 1?+-.0.06 g/cm3(Predicted)
pka8?+-.0.10(Predicted)
Safety Information
MSDS Information
PROTAC Linker 27 Usage And Synthesis
Biological ActivityTos-PEG2-NH2 (PROTAC Linker 27) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
PROTAC Linker 27 Preparation Products And Raw materials
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