4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE

4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Basic information
Product Name:4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE
Synonyms:4-methylumberiferryl-N-acetyl-beta-D-glucosaminide.2H2O;2-Oxo-4-methyl-2H-1-benzopyran-7-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside;4-Methyl-2-oxo-2H-1-benzopyran-7-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside;4-Methylumbelliferyl-β-N-acetylglucosamine;4-Methylumbelliferyl-β-N-acetylglucosaminide;4-MU-GlcNAc;7-[[2-(Acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one;4-Methylumbelliferyl-N-acetyl-beta-D-glucosaminide,99%
CAS:37067-30-4
MF:C18H21NO8
MW:379.37
EINECS:253-333-0
Product Categories:Substrates;Sugars, Carbohydrates & Glucosides;Carbohydrates & Derivatives;Fluorescent Labels & Indicators;substrate
Mol File:37067-30-4.mol
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Structure
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Chemical Properties
Melting point 208-210 °C
Boiling point 507.24°C (rough estimate)
density 1.4163 (rough estimate)
refractive index 1.5740 (estimate)
storage temp. -20°C
solubility DMF: 20 mg/mL, clear, colorless
pka12.87±0.70(Predicted)
form Crystalline solid
color White to Off-White
λmax360nm(Phosphate buffer sol.)(lit.)
BRN 1693397
Stability:Light Sensitive - Protect from Light
LogP0.340 (est)
CAS DataBase Reference37067-30-4(CAS DataBase Reference)
EPA Substance Registry System2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]oxy]-4-methyl- (37067-30-4)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
10-21
HS Code 29321900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Usage And Synthesis
Chemical Properties4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is White Crystalline Solid
Uses4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozy mes (Hex A & Hex B) result in various clinical and biochemical types of GM2 gangliosidosis. They include Tay Sachs disease, Sandhoff disease and other forms. Fluorescence: max. Abs. l = 325nm, max. Em. l = 378nm
Uses4-Methylumbelliferyl N-acetyl-β-D-glucosaminide has been used as a substrate for assaying
  • β-N-acetylglucosaminidase (NAGase) from soil samples
  • chitinase from Fusarium oxysporum using fluorimetric assay
  • β-N-acetylhexosaminidases from Arabidopsis thaliana roots and leaves samples

General Description4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) contains chitin monomer, N-acetyl-D-glucosamine (NAG) and a 4-methylumbelliferone (7-hydroxy-4-methylcoumarin) (4-MUF) moiety.
Biochem/physiol Actions4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) is a synthetic fluorogenic substrate for N-acetyl-β-D-glucosaminidase (NAGase). The enzyme functionality is assessed by its ability to hydrolyze the N-acetyl-D-glucosamine (NAG) residue in 4-MUF-NAG. 4-MUF-NAG is also a substrate for Chitinase and N-acetylhexosaminidase.
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE Preparation Products And Raw materials
4-Methylumbelliferyl 2-Acetamido-2-deoxy-4-O-(a-L- fucopyranosyl)-b-D-glucopyranoside 4-METHYLUMBELLIFERYL-N,N',N''-TRIACETYL-BETA-CHITOTRIOSIDE 4-Methylumbelliferyl 2-Acetamido-2-deoxy-3-O-(a-L-fucopyranosyl)-b-D-glucopyranoside 4-Methylumbelliferyl b-Chitotetraose Tridecaacetate 4-METHYLUMBELLIFERYL BETA-D-N,N'-DIACETYL-CHITOBIOSIDE FLUOROPENTACHLOROACETONE DEXTROSE 4-METHYLUMBELLIFERYL 4-DEOXY-B-D-CHITOBIOSE PERACETATE 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE 4-METHYLUMBELLIFERYL BETA-D-N,N',N',N''-TETRAACETYLCHITOTETRAOSIDE 4-Methylumbelliferyl3,4,6-tri-O-acetyl-2-deoxy-2-trifluoroacetamido-b-D-glucopyranoside 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE DIHYDRATE 4-METHYLUMBELLIFERYL LEWIS X TRISACCHARIDE 4-METHYLUMBELLIFERYL-N,N'-DIACETYL-BETA-D-CHITOBIOSIDE MONOHYDRATE 250 MG 4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE ANALYT. GR. 4-METHYLUMBELLIFERYL N-ACETYL-BETA-D-GLUCOSAMINIDE-6-SULFATE SODIUM SALT 4-Methylumbelliferyl 6-Sulfo-2-acetamido-2-deoxy-b-D-glucopyranoside, Potassium Salt 4-Methylumbelliferyl2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside

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