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| | 3,5-Difluoropyridine Basic information | | Synthesis |
| Product Name: | 3,5-Difluoropyridine | | Synonyms: | 3,5-DIFLUOROPYRIDINE;3,5-Difluoropyridine 98%;3,5-Difluoropyridine98%;3,5-Difluropyridine;3,5-Difluoropyridine>;Pyridine, 3,5-difluoro-;3,5-Difluoropyridine ISO 9001：2015 REACH | | CAS: | 71902-33-5 | | MF: | C5H3F2N | | MW: | 115.08 | | EINECS: | 624-636-9 | | Product Categories: | Fluorine series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridine;Chemical Synthesis;Fluorin-contained pyridine series;Halogenated Heterocycles;Heterocyclic Building BlocksHeterocyclic Building Blocks;New Products for Chemical Synthesis | | Mol File: | 71902-33-5.mol |  |
| | 3,5-Difluoropyridine Chemical Properties |
| Boiling point | 92-93°C | | density | 1.256 g/mL at 25 °C | | refractive index | 1.4437 | | Fp | 9°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | pka | 0.39±0.20(Predicted) | | color | Colorless to Almost colorless | | BRN | 7914363 | | InChIKey | WRXAZPPGFLETFR-UHFFFAOYSA-N | | CAS DataBase Reference | 71902-33-5(CAS DataBase Reference) |
| | 3,5-Difluoropyridine Usage And Synthesis |
| Synthesis | Hydrogenolysis of 2,4,6-tribromo-3,5-difluoropyridine occurred rapidly giving
quantitative conversion to 3,5-difluoropyridine (5), with an isolated yield by distillation
of 63%.
 | | Chemical Properties | Liquid | | Preparation | Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8. |
| | 3,5-Difluoropyridine Preparation Products And Raw materials |
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