Ciprofloxacin hydrochloride hydrate

Ciprofloxacin hydrochloride hydrate Basic information
Product Name:Ciprofloxacin hydrochloride hydrate
Synonyms:3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;CIPROFLOXACIN HCL/ CIPROFLOXACIN MONOHYDROCHLORIDE;CIPROFLOXACIN HCL USP;CIPROFLOXACINHYDROCHLORIDE,USP;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride hydrate;Ciprofloxacin hydrochloride hydrate;1-cyclopropyl-6-fluoro-4-keto-7-piperazin-1-yl-quinoline-3-carboxylic acid hydrate hydrochloride;1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid hydrate hydrochloride
CAS:86393-32-0
MF:C17H21ClFN3O4
MW:385.82
EINECS:617-845-1
Product Categories:Peptide Synthesis/Antibiotics;Quinolones (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Active Pharmaceutical Ingredients;Pharmaceutical raw materials
Mol File:86393-32-0.mol
Ciprofloxacin hydrochloride hydrate Structure
Ciprofloxacin hydrochloride hydrate Chemical Properties
Melting point 318-320 °C
RTECS VB1993800
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride.
form neat
color White to Light yellow
PHpH (25g/l, 25℃) 3.0~4.5
Water Solubility Soluble in water (35mg/ml).
Merck 14,2314
InChIKeyDIOIOSKKIYDRIQ-UHFFFAOYSA-N
CAS DataBase Reference86393-32-0(CAS DataBase Reference)
Safety Information
WGK Germany 3
HazardClass IRRITANT
HS Code 2933595960
MSDS Information
Ciprofloxacin hydrochloride hydrate Usage And Synthesis
Chemical PropertiesPale yellow, crystalline, slightly hygroscopic powder.
UsesFluoroquinolone antibacterial.
UsesCiprofloxacin hydrochloride has been suggested as a treatment for a wide range of infections caused by susceptible organisms including infections of urinary, respiratory, and gastrointestinal tracts, gonorrhoea and septicaemia. Nalidixic acid analogue.
ApplicationCiprofloxacin hydrochloride hydrate is a broad-spectrum antibiotic that inhibits bacterial DNA gyrase and blocks DNA synthesis and replication, resulting in bacterial death. It has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae; the antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae is better than norfloxacin and pefloxacin.
DefinitionChEBI: The monohydrate form of ciprofloxacin monohydrochloride.
Brand nameCiloxan (Alcon); Cipro (Bayer); Proquin (Esprit).
General DescriptionCiprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.
in vitroCiprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL.
in vivoCiprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.
Ciprofloxacin hydrochloride hydrate Preparation Products And Raw materials
Ciprofloxacin HCl Ciprofloxacin hydrochloride Chloral hydrate Gatifloxacinacid Isoquinoline N-Aminoethylpiperazine hydrazine hydrate QUINOLINE-3-CARBOXYLIC ACID Quinclorac Topotecan hydrochloride ISOPROPYLHYDRAZINE HYDROCHLORIDE CIPROFLOXACIN-D8 HCL (PIPERAZINE-D8) Ciprofloxacin hydrochloride hydrate Ciprofloxacin Gatifloxacin-D4 Hydrochloride fluoro jade Dihydromyrcenol hydrate

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