ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Piperazine compounds 1-Methylpiperazine

1-Methylpiperazine

1-Methylpiperazine Basic information
Product Name:1-Methylpiperazine
Synonyms:N-METHYLPIPERAZINE;NMPRZ;1-methyl-piperazin;1-METHYLPIPERAZINE FOR SYNTHESIS;Cyclizine Related CoMpound A;N-Methyl piperazine;4-Methylpiperazine;1-Methylpiperazine, 99+% 100GR
CAS:109-01-3
MF:C5H12N2
MW:100.16
EINECS:203-639-5
Product Categories:1;Benzotriazoles ,Triazoles;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Nitrogen containing;Alpha Sort;Heterocyclics;M;MAlphabetic;META - METHChemical Class;Volatiles/ Semivolatiles;Heterocyclic Building Blocks;Piperidines, Piperidones, Piperazines;Piperaizine;Piperazine derivates;Piperazines;Building Blocks
Mol File:109-01-3.mol
1-Methylpiperazine Structure
1-Methylpiperazine Chemical Properties
Melting point -6 °C
Boiling point 138 °C(lit.)
density 0.903 g/mL at 25 °C(lit.)
vapor density 3.5 (vs air)
vapor pressure 12 hPa (20 °C)
refractive index n20/D 1.466(lit.)
Fp 108 °F
storage temp. 2-8°C
solubility Chloroform (Soluble), Methanol (Soluble)
pkapK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form Liquid
Specific Gravity0.903
color Clear
PH11-12 (50g/l, H2O, 20℃)
explosive limit1.2-9.9%(V)
Water Solubility soluble
Sensitive Hygroscopic
BRN 102724
InChIKeyPVOAHINGSUIXLS-UHFFFAOYSA-N
LogP-0.57 at 25℃
CAS DataBase Reference109-01-3(CAS DataBase Reference)
NIST Chemistry ReferencePiperazine, 1-methyl-(109-01-3)
EPA Substance Registry SystemPiperazine, 1-methyl- (109-01-3)
Safety Information
Hazard Codes T,F,C,Xi
Risk Statements 10-21-23-34-36/37/38-20/21
Safety Statements 16-26-36/37/39-45-36
RIDADR UN 2734 8/PG 2
WGK Germany 2
RTECS TM1225000
Autoignition Temperature320 °C
Hazard Note Flammable/Toxic/Corrosive/Store under nitrogen
TSCA Yes
HazardClass 3
PackingGroup III
HS Code 29335995
ToxicityLD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg
MSDS Information
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1-Methylpiperazine English
ACROS English
SigmaAldrich English
ALFA English
1-Methylpiperazine Usage And Synthesis
Chemical Propertiesclear liquid
Uses1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)
Uses1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.
DefinitionChEBI: 1-Methylpiperazine is a N-methylpiperazine.
HazardModerate fire risk.
Flammability and ExplosibilityFlammable
Safety ProfilePoison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
1-Methylpiperazine Preparation Products And Raw materials
Raw materialsMethanol-->CARBON DIOXIDE-->Piperazine-->PIPERAZINE HEXAHYDRATE-->PIPERAZINE DIHYDROCHLORIDE
Preparation ProductsZopiclone-->2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde-->3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE-->2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide-->2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine-->(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol-->2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride-->(3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE-->2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid-->2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile-->3-(4-Methylpiperazin-1-ylmethyl)benzoic acid-->Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate-->4-[(4-Methylpiperazin-1-yl)methyl]aniline-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine-->CHLORCYCLIZINE HYDROCHLORIDE-->2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone-->3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one-->CHLORCYCLIZINE-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde-->Levofloxacin-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile-->4-(4-Methylpiperazino)aniline-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid-->1-METHYL-4-(4-NITROPHENYL)PIPERAZINE-->Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID-->(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID-->Clozapine-->1-METHYL-4-(3-NITROPHENYL)PIPERAZINE-->1-AdaMantanethylaMine-->1-METHYL-4-(4-NITROBENZYL)PIPERAZINE-->1-Amino-4-methylpiperazine-->1-FORMYL-4-METHYLPIPERAZINE
Piperacillin N-(3-Trifluoromethylphenyl)piperazine 1-Methylpyrrolidine 1-Methylimidazole N-Aminoethylpiperazine N-Methyl-2-pyrrolidone 1-(4-Fluorophenyl)piperazine Tribenuron methyl Piperazine 1-(4-Nitrophenyl)piperazine Kresoxim-methyl 1-((PYRROLIDINE-1-CARBONYL)METHYL)PIPERAZINE Thiophanate-methyl 1-Piperazinecarbaldehyde Methyl salicylate Ethyl N-piperazinecarboxylate Methyl acetate Methyl bromide
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