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| | Doxifluridine Basic information |
| Product Name: | Doxifluridine | | Synonyms: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone;Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine);5μdFUrd, Doxifluridine;5μdFUrd, 5-Fluoro-5μ-deoxyuridine;5’-Deoxy-5-fluomuridine;2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro- | | CAS: | 3094-09-5 | | MF: | C9H11FN2O5 | | MW: | 246.19 | | EINECS: | 221-440-1 | | Product Categories: | Heterocycles;API;Amines, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;FURTULON;Anti-cancer&immunity;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;API intermediates;Bases & Related Reagents;Nucleotides;Intermediates & Fine Chemicals;Pharmaceuticals;Pyrazines, Pyrimidines & Pyridazines;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents | | Mol File: | 3094-09-5.mol |  |
| | Doxifluridine Chemical Properties |
| Melting point | 188-192 °C(lit.) | | alpha | D25 +18.4° (c = 0.419 in water) | | density | 1.3751 (estimate) | | refractive index | 20 ° (C=1, H2O) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 7.4(at 25℃) | | color | White | | Merck | 14,3437 | | CAS DataBase Reference | 3094-09-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 2 | | RTECS | YU7526000 | | Hazard Note | Irritant | | HazardClass | IRRITANT, IRRITANT-HARMFUL | | HS Code | 29349990 | | Toxicity | LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu) |
| | Doxifluridine Usage And Synthesis |
| Description | Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is
more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers. | | Chemical Properties | White Solid | | Originator | Hoffmann-LaRoche (USA) | | Uses | antineoplastic, pyrimidine antimetabolite | | Uses | 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. | | Uses | A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity | | Uses | An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine | | Definition | ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro
racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. | | Brand name | Furtulon | | Biochem/physiol Actions | Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity. |
| | Doxifluridine Preparation Products And Raw materials |
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