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| | SB408124 Basic information |
| Product Name: | SB408124 | | Synonyms: | 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea;SB 4081241-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea;N-(6,8-DIFLUORO-2-METHYL-4-QUINOLINYL)-N'-[4-(DIMETHYLAMINO)PHENYL]UREA;SB 408124;SB-408124, CID4331799;CS-1990;SB 408124; SB408124;Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]- | | CAS: | 288150-92-5 | | MF: | C19H18F2N4O | | MW: | 356.37 | | EINECS: | 604-604-1 | | Product Categories: | Inhibitors;Orexin receptor | | Mol File: | 288150-92-5.mol |  |
| | SB408124 Chemical Properties |
| Boiling point | 430.3±45.0 °C(Predicted) | | density | 1.371 | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: ~24 mg/mL | | form | solid | | pka | 12.12±0.43(Predicted) | | color | olive-green |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | SB408124 Usage And Synthesis |
| Uses | SB 408124 is a novel OX-1 antagonist. | | Definition | ChEBI: 1-(6,8-difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea is a member of quinolines and an organohalogen compound. | | Biological Activity | Selective non-peptide orexin OX 1 receptor antagonist (K b values are 21.7 and 1405 nM for human OX 1 and OX 2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo . | | storage | Store at RT | | references | [1] langmead cj1, jerman jc, brough sj, scott c, porter ra, herdon hj.characterisation of the binding of [3h]-sb-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. br j pharmacol. 2004 jan;141(2):340-6.
[2] woldan-tambor a1, biegańska k, wiktorowska-owczarek a, zawilska jb. activation of orexin/hypocretin type 1 receptors stimulates camp synthesis in primary cultures of rat astrocytes. pharmacol rep. 2011;63(3):717-23.
[3] kis gk1, molnár ah, daruka l, gardi j, rákosi k, lászló f, lászló fa, varga c.the osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. pflugers arch. 2012 apr;463(4):531-6. |
| | SB408124 Preparation Products And Raw materials |
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