ChemicalBook Product Catalog Chemical Reagents Organic reagents Imide 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Basic information
Product Name:1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms:1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE;WATER-SOLUBLE CARBODIIMIDE;WSCD;WSCI;N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;[3-(Dimethylamino)propyl]ethylcarbodiimide
CAS:1892-57-5
MF:C8H17N3
MW:155.24
EINECS:217-579-2
Product Categories:straight chain compounds
Mol File:1892-57-5.mol
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Structure
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties
Boiling point 66-68°C/1mm
density 0.877 g/mL at 20 °C (lit.)
refractive index n20/D 1.461
Fp 66-68°C/1mm
storage temp. -20°C
solubility Chloroform
pka9.52±0.28(Predicted)
form Liquid
color Colorless to slightly yellow
Specific Gravity0.885
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 507429
InChIKeyLMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference1892-57-5(CAS DataBase Reference)
NIST Chemistry Reference1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 2735 8/PG 3
WGK Germany 3
F 1-3-10
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29252900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Usage And Synthesis
Chemical PropertiesClear light yellow liquid
Uses1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.
General DescriptionN-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials
Raw materialsDiethyl ether-->Dichloromethane-->Potassium carbonate-->Triethylamine-->Tosyl chloride-->3-Dimethylaminopropylamine-->Ethyl isocyanate
Preparation ProductsN-Succinimidyl Methacrylate-->1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE METHIODIDE O-Phthalimide Ethanol N,N-Dimethylformamide Ethyl pyruvate Ethyl formate 4-Dimethylaminobenzoic acid N,N'-Diisopropylcarbodiimide 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide N,N-Diisopropylethylamine 2-Dimethylaminoethanol ISOXADIFEN-ETHYL Lithium diisopropylamide Ethyl acetate N,N-Dimethylallylamine Ethyl acrylate Cyanamide 4-Dimethylaminopyridine
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