Diethyl oxalate

Diethyl oxalate Basic information
Product Name:Diethyl oxalate
Synonyms:AKOS BBS-00004457;Ethanedioic acid diethyl ester;ETHYL OXALATE;DIETHYL OXALATE;DIETHYL ETHANEDIOATE;RARECHEM AL BI 0114;OXALIC ACID DIETHYL ESTER;C2H5OCOCOOC2H5
CAS:95-92-1
MF:C6H10O4
MW:146.14
EINECS:202-464-1
Product Categories:C6 to C7;Carbonyl Compounds;Esters;EstersChromatography;Alpha Sort;Chemical Class;Pharmaceutical Intermediates;Organics;D;DAlphabetic;DID - DINAnalytical Standards;Food&Beverage Standards;Organic Acids;Volatiles/ Semivolatiles;Analytical Chemistry;Solvents for HPLC & Spectrophotometry;Solvents for Spectrophotometry
Mol File:95-92-1.mol
Diethyl oxalate Structure
Diethyl oxalate Chemical Properties
Melting point -41 °C (lit.)
Boiling point 185 °C (lit.)
density 1.076 g/mL at 25 °C (lit.)
vapor density 5.03 (vs air)
vapor pressure 1 mm Hg ( 47 °C)
refractive index n20/D 1.410(lit.)
Fp 168 °F
storage temp. Store below +30°C.
solubility Miscible with alcohols, ether and other common organic solvents.
form Liquid
color Clear
explosive limit0.42-2.67%(V)
Water Solubility MAY DECOMPOSE
Sensitive Moisture Sensitive
Merck 14,3125
BRN 606350
Stability:Stable, but moisture sensitive. Incompatible with strong oxidizing agents.
InChIKeyWYACBZDAHNBPPB-UHFFFAOYSA-N
LogP0.560
CAS DataBase Reference95-92-1(CAS DataBase Reference)
NIST Chemistry ReferenceEthanedioic acid, diethyl ester(95-92-1)
EPA Substance Registry SystemEthyl oxalate (95-92-1)
Safety Information
Hazard Codes Xn,T
Risk Statements 22-36-68/21-48/25-35-61-60
Safety Statements 23-45-36/37/39-28-26-25-24-53
RIDADR UN 2525 6.1/PG 3
WGK Germany 1
RTECS RO2800000
Autoignition Temperature410 °C
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29171900
Hazardous Substances Data95-92-1(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 400 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Diethyl oxalate Usage And Synthesis
Chemical Propertiescolourless liquid
Chemical PropertiesAnhydrous oxalic acid and ethanol were esterified in the presence of toluene to produce crude diethyl oxalate. The crude ester is distilled into finished product. Raw material consumption quota: 985kg / T oxalic acid, 744kg / T ethanol (95%) and 73.4kg/t toluene. Another preparation method is to add ethanol, benzene and oxalic acid into the reactor, heat it to 68 ℃, azeotrope reflux dehydration, and take no water out as the end point of the reaction, then recover benzene to obtain crude diethyl oxalate, distill under reduced pressure, and collect 103 ℃ / 6kpa fraction to diethyl oxalate. It is purified by washing with dilute sodium carbonate solution, drying anhydrous potassium carbonate or sodium sulfate and vacuum distillation.
Another preparation method is to add 45g (0.5mol) of anhydrous oxalic acid ① (2), 81g (1.76mol) of anhydrous ethanol, 200ml of benzene and 10ml of concentrated sulfuric acid into the reaction bottle equipped with agitator and water separator. It is heated under stirring and refluxed at 68 ~ 70 ℃ for azeotropic dehydration. After the water is basically evaporated, ethanol and benzene are evaporated. Wash with water after cooling, wash with saturated sodium bicarbonate solution, wash with water, and dry with anhydrous sodium sulfate. Diethyl oxalate (57g) was obtained by atmospheric distillation and collecting the fraction at 182 ~ 184 ℃, with a yield of 78%. ① dehydrate oxalic acid with anhydrous chloroform water until it crystallizes as follows: steam it with anhydrous oxalic acid and inject it into the powder containing carbon. Filter by suction, dry and store in dryer for standby. Anhydrous oxalic acid can also be prepared by drying directly in an oven. In this experiment, a corresponding amount of oxalic acid containing crystal water can also be used, but the reaction time is longer.
Usesmanufacture of phenobarbital, ethylbenzyl malonate, triethylamine, and similar chemicals, plastics, dyestuff intermediates. Solvent for cellulose esters, perfumes.
UsesDiethyl oxalate is used to prepare active pharmaceutical ingredients (API), plastics and dyestuff intermediates. It is also used as a solvent for cellulose esters, ethers, resins, perfumes and lacquers for electronics. It is involved in the transesterification reaction with phenol to get dipheny oxalate. It is also involved in the Claisen condensation ketosteroids to prepare glyoxalyl derivatives. Further, it is used to prepare sym-1,4-diphenyl-1,4-dihydro-1,2,4,5-polytetrazine. In addition to this, it is utilized in the microemulsion synthesis of zinc oxide nanoparticles.
ApplicationDiethyl oxalate has the general properties of esters. It absorbs moisture in the air and decomposes slowly. It reacts with ammonia to form amide compounds and condenses with acetone to ethyl pyruvate. It is mainly used in the pharmaceutical industry. It is an intermediate of azathioprine, peripheral sulfanilamide, carboxyphenyllipase penicillin, ethoxybenzylpenicillin, chloroquine lactate, thiabendazole, sulfamethoxazole and other drugs. It can be used as an intermediate of plastics, dyes and other products, and as a solvent of cellulose and spices.
Diethyl acetate is often used as the substrate of nucleophilic reagent α,γ- Dicarbonyl esters, ketone compounds, synthesis of heterocyclic compounds, etc. synthesis α,γ- Dicarbonyl esters can be formed by nucleophilic substitution reaction between ketones and diethyl oxalate under alkaline conditions α,γ- Dicarbonyl ester (formula 1). The dicarbonyl ester often exists in enol structure and can be used to synthesize heterocyclic compounds (formula 2)
synthesize heterocyclic compounds
Production MethodsDiethyl oxalate is produced via esterification of ethanol and oxalic acid. It is a preferred solvent for cellulose acetate and nitrate.
General DescriptionA colorless liquid. Flash point 168°F. Slightly denser than water and insoluble in water. Hence sinks in water. May irritate skin and mucous membranes; may be mildly toxic by ingestion; may emit irritating fumes in a fire. Vapors are much heavier than air. Used as a solvent for plastics and in the manufacture of perfumes and pharmaceuticals.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileDiethyl oxalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides
HazardToxic by ingestion, strong irritant to skin and mucous membranes.
Health HazardTOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardCombustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety ProfilePoison by ingestion. Flammable liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also OXALATES and ESTERS.
Diethyl oxalate Preparation Products And Raw materials
Raw materialsEthanol-->Methanol-->Toluene-->Oxalic acid
Preparation Products5-(3-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID-->3-Phenyl-1H-pyrazole-5-carboxamide ,97%-->3-(4-CHLOROPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE-->ETHYL 5-METHYLISOXAZOLE-3-CARBOXYLATE-->1-Methyl-5-propyl-1H-pyrazole-3-carboxylic acid amide ,97%-->3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide ,97%-->5-Methyl-1H-pyrazole-3-carboxylic acid-->4-BROMO-5-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID-->Cromolyn Disodium Salt-->Gliclazide-->5-TERT-BUTYL-1H-PYRAZOLE-3-CARBOXYLIC ACID-->1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLIC ACID-->Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate-->ETHYL 3-(4-CHLOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLATE-->5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER-->1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID-->Ethyl 5-(tert-butyl)-2H-pyrazole-3-carboxylate-->ETHYL 5-(2-FURYL)-1H-PYRAZOLE-3-CARBOXYLATE-->ETHYL 5-(3-NITROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE-->ETHYL 1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLATE-->Ethyl 3-(3-chlorophenyl)-1H-pyrazole-5-carboxylate ,97%-->5-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE-->4-Fluoroindole-->2,2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid-->5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER-->Ethyl 3-(5-methylfuran-2-yl)-1H-pyrazole-5-carboxylate ,97%-->ETHYL 2-(1-METHYL-1H-IMIDAZOL-2-YL)-2-OXOACETATE-->3-(tert-Butyl)-1H-pyrazole-5-carbohydrazide-->5-Chloroindole-->OROTIC ACID MONOHYDRATE-->5-Fluoroindole-2-carboxylic acid-->ETHYL 2,4-DIOXOHEPTANOATE-->Ethyl 2,4-dioxovalerate-->dimethyl 4-chloropyridine-2,6-dicarboxylate-->ETHYL PROPIONYL PYRUVATE-->ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE-->DIETHYL OXALPROPIONATE-->Imazamox
VINYL ESTER RESIN Diethyl oxalacetate Ethyl bromodifluoroacetate Diethyl adipate OXALIC ACID Diethyl phthalate Tris(trimethylsilyl)phosphate Diethyl methylmalonate Diethyl azodicarboxylate Diethyl ether Mefenpyr-diethyl DIETHYL PHOSPHATE Diethyl pimelate Methyl acrylate Diethyl malonate Diethyl carbonate Diethyl sulfate Diethyl succinate

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.