2'-Methoxyacetophenone

2'-Methoxyacetophenone Basic information

Product Name:	2'-Methoxyacetophenone
Synonyms:	AKOS BBS-00003280;2-ACETYLANISOLE;2-ACETOANISOLE;2-ACETANISOLE;2'-METHOXYACETOPHENONE;JR-8523, 1-(2-Methoxyphenyl)ethanone, 97%;-Chloro-biphenyl-4-yl)-2-oxo-ethyl]acrylic acid;2-METHOXYACETOPHENONE
CAS:	579-74-8
MF:	C9H10O2
MW:	150.17
EINECS:	209-446-2
Product Categories:	Building Blocks;C9;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;Aromatic Acetophenones & Derivatives (substituted)
Mol File:	579-74-8.mol

2'-Methoxyacetophenone Chemical Properties

Melting point	117–119°C
Boiling point	131 °C18 mm Hg(lit.)
density	1.09 g/mL at 25 °C(lit.)
FEMA	4163 \| 2-METHOXYACETOPHENONE
refractive index	n20/D 1.5393(lit.)
Fp	228 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Sparingly), Methanol (Sparingly)
form	Liquid
color	Clear slightly yellow to orange or slightly brown
Odor	at 1.00 % in propylene glycol. powdery anisic almond phenolic
Odor Type	anisic
Water Solubility	immiscible
Sensitive	Light Sensitive
JECFA Number	2042
BRN	1100602
LogP	1.82
CAS DataBase Reference	579-74-8(CAS DataBase Reference)
NIST Chemistry Reference	Ortho-methoxyacetophenone(579-74-8)
EPA Substance Registry System	Ethanone, 1-(2-methoxyphenyl)- (579-74-8)

Safety Information

MSDS Information

2'-Methoxyacetophenone Usage And Synthesis

Chemical Properties	clear slightly yellow to orange or slightly
Chemical Properties	Colorless to pale yellow clear liquid; powdery anisic almond phenolic aroma.
Uses	2''-Methoxyacetophenone is a useful building block, often used in the preparation of chalcones, such as the chalcones of 3-benzylidene-2-chlorocyclohex-1-enecarbaldehyde for use as potential anti-proliferative agents.
Preparation	Preparation by reaction of dimethyl sulfate with o-hydroxyacetophenone in the presence of sodium hydroxide.
Aroma threshold values	Anisic-type, medium strength odor; recommend smelling in a 1.00% solution or less.
Taste threshold values	Powdery musty anisic almond taste at 30 ppm in water.
Synthesis Reference(s)	Tetrahedron Letters, 22, p. 2605, 1981 DOI: 10.1016/S0040-4039(01)90532-5 Journal of the American Chemical Society, 72, p. 5161, 1950 DOI: 10.1021/ja01167a100 The Journal of Organic Chemistry, 52, p. 150, 1987 DOI: 10.1021/jo00377a027

2'-Methoxyacetophenone Preparation Products And Raw materials

Raw materials	Benzene, 1-methoxy-2-(1-methylethenyl)--->2-ETHYLANISOLE-->1-(2-METHOXYPHENYL)ETHANOL-->2-METHOXYSTYRENE-->1-Methoxy-2-(prop-2-yn-1-yl)benzene-->1-ETHYNYL-2-METHOXYBENZENE-->2'-Hydroxyacetophenone
Preparation Products	2-METHOXYACETOPHENONE-->ETHYL (2-METHOXYBENZOYL)ACETATE-->1,3-bis(2-methoxyphenyl)propane-1,3-dione-->Ethyl 2-Methoxy-a,g-dioxo-benzenebutanoate-->3-[2-(2-methoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one-->1H-Pyrazole-4-carboxaldehyde, 3-(2-methoxyphenyl)-1-phenyl--->2-METHOXYCHALCONE

Login