4-Nitrobenzeneethanol

4-Nitrobenzeneethanol Basic information
Product Name:4-Nitrobenzeneethanol
Synonyms:p-Nitrophenylethyl alcohol;4-Nitrophenethyl Alcohol 2-(4-Nitrophenyl)ethyl Alcohol;Benzeneethanol,4-nitro-;4-Nitrobenzeneethanol, 99%, 99%;4-Nitrophenethyl alcohol,2-(4-Nitrophenyl)ethanol;2-(4-Nitrophenyl)ethan-1-ol, 4-(2-Hydroxyethyl)nitrobenzene;2-(4-Nitrophenyl)ethanol, 99+%;SS-P-NITROPHENYLETHANOL
CAS:100-27-6
MF:C8H9NO3
MW:167.16
EINECS:202-835-8
Product Categories:Aromatic alcohols and diols
Mol File:100-27-6.mol
4-Nitrobenzeneethanol Structure
4-Nitrobenzeneethanol Chemical Properties
Melting point 59-62 °C(lit.)
Boiling point 177 °C16 mm Hg(lit.)
density 1.2917 (rough estimate)
refractive index 1.5570 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
form Solid
pka14.57±0.10(Predicted)
color White to Light Brown
Water Solubility <0.01 g/100 mL at 18 ºC
BRN 1866148
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference100-27-6(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneethanol, 4-nitro-(100-27-6)
EPA Substance Registry System4-Nitrobenzeneethanol (100-27-6)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22-36-40-36/37/38
Safety Statements 22-24/25-26-36
WGK Germany 3
RTECS SG8602000
Hazard Note Irritant
TSCA Yes
HS Code 29062990
MSDS Information
ProviderLanguage
2-(p-Nitrophenyl)ethanol English
SigmaAldrich English
4-Nitrobenzeneethanol Usage And Synthesis
Chemical Propertiesyellow to orange crystalline powder
Uses4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2''-deoxyinosine-containing oligodeoxyribonucleotide duplexes.
Synthesis Reference(s)The Journal of Organic Chemistry, 38, p. 2786, 1973 DOI: 10.1021/jo00956a011
General DescriptionYellow needles (from aqueous methanol) or orange solid.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileA nitrated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health HazardSYMPTOMS: Structurally similar chemicals may cause methemoglobinemia.
Fire HazardFlash point data for 4-Nitrobenzeneethanol are not available; however, 4-Nitrobenzeneethanol is probably combustible.
4-Nitrobenzeneethanol Preparation Products And Raw materials
Preparation Products4-Nitrophenethylamine hydrochloride-->4-(2-HYDROXYETHYL)BENZONITRILE-->2-(4-Aminophenyl)ethanol
4-NITRO-1-NAPHTHALENE ACETIC ACID 2-Nitrobenzeneethanol BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE 3-Nitrobenzeneethanol (2R,3R)-(+)-2,3-EPOXY-3-(4-NITROPHENYL)-1-PROPANOL 2-OXOPROPYL 2-(4-NITROPHENYL)ACETATE 2-(4-NITROPHENYL)PROPIONIC ACID 4-Nitrobenzeneethanol 4-NITROPHENYLSUCCINIC ACID BIS(2,4-DINITROPHENYL)ACETIC ACID ETHYL ESTER N-SUCCINIMIDYL 4-NITROPHENYLACETATE METHYL 2,4-DINITROPHENYLACETATE 4-NITROPHENYLACETIC ACID SODIUM SALT (2S 3S)-(-)-3-(4-NITROPHENYL)GLYCIDOL [2-(METHOXYMETHOXY)PHENYL][3-(4-NITROPHENYL)OXIRAN-2-YL]METHANONE Nitrophenyl 4-NITROPHENYLGLYOXYLIC ACID 2-Nitrobenzeneethanol acetate

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