Fmoc-O-(benzylphospho)-L-threonine

Fmoc-O-(benzylphospho)-L-threonine Basic information
Product Name:Fmoc-O-(benzylphospho)-L-threonine
Synonyms:FMOC-THR(PO(OBZL)OH)-OH;FMOC-THR(HPO3BZL)-OH;FMOC-THREONINE(PO(OBZL)OH)-OH;FMOC-L-THR(PO(OBZL)OH);FMOC-L-THR(PO(OBZL)OH)-OH;FMOC-O-BENZYL-L-PHOSPHOTHREONINE;N-ALPHA-FMOC-O-BENZYL-L-PHOSPHOTHREONINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-BENZYLOXY-PHOSPHONO-L-THREONINE
CAS:175291-56-2
MF:C26H26NO8P
MW:511.46
EINECS:
Product Categories:amino acids;a-amino;Unusual amino acids;Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
Mol File:175291-56-2.mol
Fmoc-O-(benzylphospho)-L-threonine Structure
Fmoc-O-(benzylphospho)-L-threonine Chemical Properties
density 1.377±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Solid
pka1.42±0.50(Predicted)
Sensitive Moisture Sensitive
InChIKeyHOFDVXHILSPFNS-OSPHWJPCSA-N
CAS DataBase Reference175291-56-2(CAS DataBase Reference)
Safety Information
WGK Germany 3
10-21
MSDS Information
ProviderLanguage
SigmaAldrich English
Fmoc-O-(benzylphospho)-L-threonine Usage And Synthesis
Chemical PropertiesWhite to off-white powder
UsesBuilding block for the synthesis of phosphothreonine containing peptides. T.Wakamiya et al., Chem. Lett. , 1994, 1099 T.Vorherr and W.Bannwarth, Bioorg. Med. Chem. Lett 5, 2661 (1995)
UsesFmoc-O-(Benzylphospho)-L-threonine, is a synthetic peptide used in the synthesis of macrocyclic peptidomimetics as pololike kinase 1 polo-box domain-binding inhibitors.
Fmoc-O-(benzylphospho)-L-threonine Preparation Products And Raw materials
Fmoc-O-(benzylphospho)-L-serine N-alpha-FMOC-Nepsilon-BOC-L-Lysine Benzyl chloride Benzyltriethylammonium chloride Dibenzyl phosphate Fmoc-O-(benzylphospho)-L-threonine Nalpha-Fmoc-Ndelta-trityl-L-glutamine FMOC-THR(TBU)-OL L-Threonine DL-O-Phosphoserine 9-Fluorenylmethyl chloroformate FMOC-D-ALLO-THREONINOL Fmoc-Phe-OH Benzyl chloroformate 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid Benzyl benzoate CHLOROPHOSPHONAZO III N-(9-Fluorenylmethoxycarbonyloxy)succinimide

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