ChemicalBook Product Catalog Chemical Reagents Organic reagents Thiol / thiol 5-Chlorothiophene-2-sulfonyl chloride

5-Chlorothiophene-2-sulfonyl chloride

5-Chlorothiophene-2-sulfonyl chloride Basic information
Product Name:5-Chlorothiophene-2-sulfonyl chloride
Synonyms:TIMTEC-BB SBB003378;5-Chlorothiophene-2-sulfonyl chloride 96%;5-CHLORO-2-THIENYLSULFONYL CHLORIDE;5-CHLORO-2-THIOPHENESULFONYL CHLORIDE;5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE;5-CHLOROTHIOPHENE-2-SULPHONYL CHLORIDE;5-CHLOROTHIOPHENESULPHONYL CHLORIDE;ART-CHEM-BB B019398
CAS:2766-74-7
MF:C4H2Cl2O2S2
MW:217.09
EINECS:
Product Categories:Building Blocks;C4 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-oher series;Heterocycles;Thiophene&Benzothiophene;Thiophene intermediates;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiophenes;ThiophenesBuilding Blocks
Mol File:2766-74-7.mol
5-Chlorothiophene-2-sulfonyl chloride Structure
5-Chlorothiophene-2-sulfonyl chloride Chemical Properties
Melting point 25-28°C
Boiling point 112-117 °C (lit.)
density 1.623 g/mL at 25 °C (lit.)
refractive index n20/D 1.586(lit.)
Fp >230 °F
storage temp. 2-8°C
form solid
color Colorless to Yellow to Orange
Specific Gravity1.623
Water Solubility Not miscible in water.
Sensitive Moisture Sensitive
BRN 130710
InChIKeySORSTNOXGOXWAO-UHFFFAOYSA-N
CAS DataBase Reference2766-74-7(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34-29-14
Safety Statements 26-27-36/37/39-45-28A-25
RIDADR UN 3265 8/PG 2
WGK Germany 3
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29349990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
5-Chlorothiophene-2-sulfonyl chloride Usage And Synthesis
Chemical Properties5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid
Uses5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
Uses5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
Synthesis Reference(s)Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6
General Description5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.
5-Chlorothiophene-2-sulfonyl chloride Preparation Products And Raw materials
Raw materialsDiethyl ether-->Phosphorus pentachloride-->Chlorosulfonic acid-->2-Chlorothiophene
Methylene Chloride 3-BROMO-5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE,3-Bromo-5-chlorothiophene-2-sulfonyl chloride, 95+% Ethanesulfonyl chloride 4-Bromo-5-chlorothiophene-2-sulfonyl chloride, 95+%,4-BROMO-5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE,3-BROMO-2-CHLOROTHIOPHENE-5-SULFONYL CHLORIDE Benzyl chloride 5-CHLORO-4-NITROTHIOPHENE-2-SULFONYL CHLORIDE Calcium chloride 5-Chlorothiophene-2-sulfonyl chloride Chloromethanesulfonyl chloride Choline chloride Tosyl chloride Sulfuryl chloride Benzenesulfonyl chloride Ammonium chloride 4-Nitrobenzenesulfonyl chloride Mepiquat chloride Polyvinyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile
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