ChemicalBook Product Catalog Chemical Reagents Organic reagents Urea 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA

1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA

1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Basic information
Product Name:1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA
Synonyms:Elagolix Impurity 14;1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA;(2-Fluoro-6-trifluoromethyl-benzyl)-urea;elagolix intermediate 3;1-(2-fluoro-6-(trifluoromethyl)benzyl)urea;1-2-Fluoro-6-trifluoromethylbenzyl urea;{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea;Eelagolix-2
CAS:830346-46-8
MF:C9H8F4N2O
MW:236.17
EINECS:
Product Categories:
Mol File:830346-46-8.mol
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Structure
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Chemical Properties
Boiling point 268.8±40.0 °C(Predicted)
density 1.392±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka12.86±0.46(Predicted)
Safety Information
MSDS Information
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Usage And Synthesis
Uses1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
SynthesisSynthesis_830346-46-8
In a 250 ml three-necked flask, 3.4 g of E6, 20 ml of water, 4.23 g of urea, and hydrochloric acid (12 mol / L, 2 ml) were added. After refluxing for 3 hours, the reaction solution was cooled to 4 ?? C with an ice water bath, and filtered to obtain 3.78 g of a white solid ( Yield: 91%).
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Preparation Products And Raw materials
Preparation Products5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione
Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester 2-Pyrrolidinone, 1-[(1R)-2-hydroxy-1-phenylethyl]- (R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate Carbamic acid, (1-phenylethenyl)-, 1,1-dimethylethyl ester (9CI) 3-Bromo-2-fluoroanisole 1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Benzeneacetic acid, 4-fluoro-.alpha.-(1-methylethyl)-, (.alpha.S)- elagolix (R)-1,2-Diamino-1-phenylethane Elagolix Sodium impurity4 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole 2,2'-difluoro-3,3'-dimethoxy-1,1'-biphenyl 5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione LEE011 (hydrochloride) 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione
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