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| | CORTISOL-9,11,12,12-D4 Basic information |
| Product Name: | CORTISOL-9,11,12,12-D4 | | Synonyms: | 17-Hydroxycorticosterone-9,11,12,12-d4, Cortisol-9,11,12,12-d4, Hydrocortisone-9,11,12,12-d4, Kendall's compound F (9,11,12,12-d4), Reichstein's substance M (9,11,12,12-d4), 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4), 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4);CORTISOL-9,11,12,12-D4;HYDROCORTISONE (9,11,12,12-D4);Cortisol-D4 (9,11,12,12-D4);(11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione-d4;11β-Hydroxycortisone-d4;17-Hydroxycorticosterone-d4;Acticort-d4 | | CAS: | 73565-87-4 | | MF: | C21H26D4O4 | | MW: | 350.49 | | EINECS: | 694-327-1 | | Product Categories: | Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Steroids | | Mol File: | 73565-87-4.mol |  |
| | CORTISOL-9,11,12,12-D4 Chemical Properties |
| Melting point | 211-214 °C | | Fp | 9℃ | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water | | form | Solid | | color | White to Off-White |
| | CORTISOL-9,11,12,12-D4 Usage And Synthesis |
| Description | Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease. | | Chemical Properties | White Solid | | Uses | Anti-inflammatory hormone | | Uses | Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. | | General Description | Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome. |
| | CORTISOL-9,11,12,12-D4 Preparation Products And Raw materials |
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