NOSCAPINE HYDROCHLORIDE

NOSCAPINE HYDROCHLORIDE Basic information
Product Name:NOSCAPINE HYDROCHLORIDE
Synonyms:NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;capvalhydrochloride;coscopinhydrochloride;coscotabshydrochloride
CAS:912-60-7
MF:C22H24ClNO7
MW:449.88
EINECS:213-014-9
Product Categories:Inhibitors
Mol File:912-60-7.mol
NOSCAPINE HYDROCHLORIDE Structure
NOSCAPINE HYDROCHLORIDE Chemical Properties
Melting point 221-223 °C(lit.)
storage temp. 2-8°C
solubility Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
form neat
color Crystals
Merck 13,6752
EPA Substance Registry System1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22
Safety Statements 36
RIDADR 1544
WGK Germany 3
RTECS NP7225000
10
HS Code 2939.19.5000
HazardClass 6.1(b)
PackingGroup III
Toxicitycyt-ham:fbr 60 mg/L ESKHA5 96,55,78
MSDS Information
ProviderLanguage
SigmaAldrich English
NOSCAPINE HYDROCHLORIDE Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder or colourless crystals, hygroscopic.
Usestopical fluoroquinolone antibiotic for acne
UsesAnti-Tussive
UsesNoscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.
Biological ActivityOpioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Safety ProfilePoison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
NOSCAPINE HYDROCHLORIDE Preparation Products And Raw materials
(+)-B-HYDRASTINE HCL 2-Amino-1,2-diphenylethanol hydrochloride 5-HYDROXYDOPAMINE HYDROCHLORIDE (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol SALOR-INT L498696-1EA 2-(1-aminoethyl)phenol (±)-alpha-[(ethylamino)methyl]-m-hydroxybenzyl alcohol dl Normetanephrine 3-Methoxysalicylic acid 2-METHOXY-5-METHYLBENZOIC ACID DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE TIMTEC-BB SBB006457 Phenol, 2-[(1S)-1-aminoethyl]-3-methyl- (9CI) Methyl 3-methoxysalicylate dioxifedrine 2-(PHENETHYLAMINO)-1-PHENYL-1-ETHANOL NOSCAPINE HYDROCHLORIDE HYDRATE

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