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| | CEPHALEXIN MONOHYDRATE Basic information |
| | CEPHALEXIN MONOHYDRATE Chemical Properties |
| Melting point | >161°C (dec.) | | refractive index | 154 ° (C=0.5, H2O) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | NH4OH 1 M: 50 mg/mL, clear, yellow | | form | solid | | color | White to Light Beige | | Water Solubility | 13.5g/L(25 ºC) | | Merck | 14,1974 | | BRN | 965503 | | Stability: | Unstable in Solution | | InChIKey | AVGYWQBCYZHHPN-KJTIIWGRSA-N | | CAS DataBase Reference | 23325-78-2(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 42/43 | | Safety Statements | 22-36/37-45-24/25 | | WGK Germany | 3 | | RTECS | XI0350000 | | HS Code | 29419052 | | Toxicity | LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles) |
| | CEPHALEXIN MONOHYDRATE Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Originator | Ceporex,Glaxo,UK,1970 | | Uses | Cephalosporin antibacterial. | | Uses | A semisynthetic cephalorsporin antibiotic. | | Uses | Semi-synthetic cephalosporin antibiotic. | | Definition | ChEBI: The hydrate of cephalexin. | | Manufacturing Process | To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g
sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared
from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was
cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine
(0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7-
aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride
salt was added, followed by triethylamine (12.1 ml) and dimethylformamide
(140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2
hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To
the resultant solution, hydrochloric acid (54 ml) was added followed by zinc
(21.8 g) in portions over a period of 5 minutes, the temperature being
maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and
the solution stirred at 15°C to 20°C for 7 hours.
The pH was adjusted to 3.3 with triethylamine and
semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to
pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The
resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of
triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200
ml) and the cephalexin recovered, yield 75%. | | Brand name | Keflex (Panixine (Ranbaxy). | | Therapeutic Function | Antibiotic |
| | CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials |
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