Cyclopropanecarboxaldehyde

Cyclopropanecarboxaldehyde Basic information

Product Name:	Cyclopropanecarboxaldehyde
Synonyms:	CYCLOPROPANECARBOXALDEHYDE;RARECHEM AK ML 0578;Cyclopropanecarboxyldehyde;Cyclopropanecarboxaldehyde ,98%;Cyclopropanecarboxaldehyde, 98% 5GR;Cyclopropanecarboxal;Cyclopropanecarboxaldehyde 98%;Cyclopropanecarboxaldehyde >
CAS:	1489-69-6
MF:	C4H6O
MW:	70.09
EINECS:	620-777-5
Product Categories:	Pharmaceutical Intermediates;Cyclopropanes;Simple 3-Membered Ring Compounds;Aldehydes;C1 to C6;Carbonyl Compounds;Pharmaceutical intermdiate;bc0001
Mol File:	1489-69-6.mol

Cyclopropanecarboxaldehyde Chemical Properties

Boiling point	98-101 °C (lit.)
density	0.938 g/mL at 25 °C (lit.)
refractive index	n20/D 1.4298(lit.)
Fp	45 °F
storage temp.	2-8°C
solubility	soluble in Chloroform
form	clear liquid
color	Colorless to Light orange to Yellow
Water Solubility	Soluble in water.
Sensitive	Air Sensitive
BRN	906781
Stability:	Volatile
InChIKey	JMYVMOUINOAAPA-UHFFFAOYSA-N
CAS DataBase Reference	1489-69-6(CAS DataBase Reference)
NIST Chemistry Reference	Cyclopropanecarboxaldehyde(1489-69-6)
EPA Substance Registry System	Cyclopropanecarboxaldehyde (1489-69-6)

Safety Information

Hazard Codes	F,C
Risk Statements	11-34
Safety Statements	16-26-36/37/39-45
RIDADR	UN 2924 3/PG 2
WGK Germany	3
RTECS	GZ1005000
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29122990

MSDS Information

Provider	Language
Cyclopropanecarboxaldehyde	English
SigmaAldrich	English
ACROS	English
ALFA	English

Cyclopropanecarboxaldehyde Usage And Synthesis

Chemical Properties	clear colorless liquid
Uses	Cyclopropanecarboxaldehyde reacts with Grignard or organolithium reagents to give the expected secondary alcohols. These are susceptible to ring opening in the presence of HBr, providing stereoselective access to homoallylic bromides. It is also used in the synthesis of eta(2)-enonenickel complexes by reacting with [Ni(cod)(2)] (cod = 1,5-cyclooctadiene) and PBu(3) and to prepare a cyclopropylidene tetralone which underwent an enantioselective palladium-catalyzed [3+2] TMM cycloaddition providing a chiral spiro-fused cyclopentene.
Definition	ChEBI: Cyclopropanecarbaldehyde is an organooxygen compound.
Application	Cyclopropanecarboxaldehyde is a reagent in the preparation of N-alkylphenylalaninamides of pyridinylphenyland oxobipyridinylamines as human GPR 142 agonists for potential use as anti-diabetic agents and the cytochrome P 450 inhibition.
Preparation	Cyclopropanecarboxaldehyde is prepared by reaction of cyclopropylmethanol. The reaction needs reagent pyridinium chlorochromate and solvent CH2Cl2 with other condition of ambient temperature for 3 hours. The yield is about 60%.

Cyclopropanecarboxaldehyde Preparation Products And Raw materials

Raw materials	Dichloromethane-->Magnesium sulfate-->Triethylamine-->Sodium hypochlorite-->Oxalyl chloride-->Potassium Phosphate Monobasic-->Potassium bromide-->Pyridinium chlorochromate-->2,2,6,6-Tetramethylpiperidinooxy-->Cyclopropyl carbinol-->Cyclopropyl bromide
Preparation Products	1-(CYCLOPROPYLMETHYL)PIPERAZINE-->N-Boc-4-(Cyclopropylmethyl)piperazine-->Cyclopropyl phenyl ketone-->Methyl cyclopropane carboxylate-->4-Cyclopropyl-1(3)H-iMidazole-->1H-Benzimidazole, 2-cyclopropyl-5,6-dimethyl--->2-Thiazolemethanol, α-cyclopropyl-4,5-dimethyl--->N-(4-IODOPHENYL)CYCLOPROPANECARBOXAMIDE-->(cyclopropylmethyl)(2,2-dimethoxyethyl)amine

Cyclopropyl phenyl ketone Ciprofloxacin hydrochloride DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI) Cyclopropanecarboxaldehyde, 2-(1,5-hexadien-3-ynyl)-, [1S-[1alpha,2alpha(E)]]- (9CI) Cyclopropanecarboxaldehyde, 1-spiro[2.3]hex-1-en-4-yl- (9CI) Cyclopropanecarboxaldehyde, 2-butyl-2-ethynyl-, trans- (9CI) Cyclopropanecarboxaldehyde, 2-acetyl-, (1R-cis)- (9CI) Cyclopropanecarboxaldehyde, 2-cyclohexyl-, cis- (9CI) ETHYL 2-FORMYL-1-CYCLOPROPANECARBOXYLATE Cyclopropanecarboxaldehyde, 2-butyl-1-methyl-, (1R,2S)-rel- (9CI) Cyclopropanecarboxaldehyde, 2-(6-methoxy-3-pyridinyl)-, (1R,2R)-rel- (9CI) Cyclopropanecarboxaldehyde, 2-phenyl-, (1R,2S)- (9CI) Cyclopropanecarboxaldehyde, 2-phenyl-, (1S,2R)- (9CI) Ciprofloxacin lactate 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID METHYL 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLATE Cyclopropanecarboxaldehyde, 2-hexyl-, (1S,2R)- (9CI)

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