Esculentoside A

Esculentoside A Basic information
Product Name:Esculentoside A
Synonyms:ESCULENTOSIDE A;Esculentoside;(2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester;Phytolaccasaponin E;Esculentoside A, 98%, from Phytolacca acinosa Roxb.;Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)-;Esculentoside A USP/EP/BP
CAS:65497-07-6
MF:C42H66O16
MW:826.96
EINECS:
Product Categories:Saponins;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:65497-07-6.mol
Esculentoside A Structure
Esculentoside A Chemical Properties
Melting point >192°C (dec.)
Boiling point 936.7±65.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka4.39±0.70(Predicted)
form Solid
color Pale Yellow
Stability:Hygroscopic
Safety Information
Safety Statements 24/25
HS Code 29389090
MSDS Information
Esculentoside A Usage And Synthesis
UsesEsculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500
PharmacokineticsEsculentoside A is a triterpenoid saponin isolated from the root of Phytolacca esculenta. Studies have revealed that this triterpenoid exhibits a strong anti-inflammatory property. Ci et al. (2015) observed the anti-inflammatory potency of esculentoside A against allergic airway inflammation in a mouse model. They found that the drug enhanced nuclear Nrf-2 translocation in the lungs of ovalbumin-challenged mice and also decreased airway inflammation (Ci et al., 2015). Esculentoside A enhanced the intracellular anti-oxidant potentials, reduced Th2 cytokine level and down-regulated the expression of adhesion molecule mRNA in lung tissues. Zhang et al. (2014) found that esculentoside A could rectify carbon tetrachlorideinduced acute liver injury in mice. The drug successfully cured the histopathological damage induced by carbon tetrachloride. Rectification has been also noted through the down-regulation of inflammatory molecules and oxidative stresses associated with PPAR-γ, NF-κB and ERK signal pathways (Zhang et al., 2014). Ma et al. (2013) analyzed the role of esculentoside A on lupus nephritis-induced BXSB mice (where male SB/Le mice and female C57BL/6 mice were hybridized, creating a recombinant inbred species). They observed that esculentoside A application significantly reduced urine protein excretion and improved renal function by promoting apoptosis of glomerular intrinsic cells and renal tubular epithelial cells (Ma et al., 2013). The efficacy was also aided by the down-regulation of inflammatory cytokines.
Wang et al. (2016) elucidated the role of esculentoside A against acetaminophen-induced liver toxicity in mice and observed that Nrf2-regulated the survival mechanism via the AMPK/ Akt/GSK3β pathway.
Esculentoside A Preparation Products And Raw materials
Escin beta-Amyrin DIETHYLMALONIC ACID 2-HEPTYL-MALONIC ACID Ginsenoside Rh2 Esculentoside A TRIBULOSIDE 1,12-Dodecanediol, 2,11-dimethyl-2,11-dipropyl- POKEWEED MITOGEN 2-HEXADECYL-MALONIC ACID Escin sodium decylmalonic acid Ginsenosides Ginsenoside Rb1 trans-4-Ethylcyclohexanecarboxylic acid trans-4-Hexylcyclohexanecarboxylic acid METHYL 15-METHYLHEPTADECANOATE Saponin

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