bupivacaine hydrochloride

bupivacaine hydrochloride Basic information
Product Name:bupivacaine hydrochloride
Synonyms:2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride;2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride (6CI);Marcaina;1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide,hydrochloride (1:1);BUPIVACAINE HYDROCHLORIDE ANHYDROUS;Bicain;Marcain;1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride
CAS:18010-40-7
MF:C18H28N2O.ClH
MW:0
EINECS:241-917-8
Product Categories:Marcain
Mol File:18010-40-7.mol
bupivacaine hydrochloride Structure
bupivacaine hydrochloride Chemical Properties
Melting point 257°C(dec.)(lit.)
storage temp. 4°C, protect from light
Water Solubility Soluble in water
solubility ≥10.25 mg/mL in DMSO; ≥16.23 mg/mL in H2O with ultrasonic; ≥69.2 mg/mL in EtOH
form neat
color White to Almost white
Stability:Hygroscopic
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 22-36/37/39-45
RIDADR UN 2811 6.1/PG 2
RTECS TK6125000
HS Code 2933.39.9200
HazardClass 6.1
PackingGroup II
ToxicityLD50 oral in rabbit: 18mg/kg
MSDS Information
bupivacaine hydrochloride Usage And Synthesis
OriginatorCarbostesin,Astra,W. Germany,1967
UsesLocal anesthesic;Na+ channel blocker
DefinitionChEBI: A racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic.
Manufacturing Process121 parts by weight of 2.6-xylidine are heated with 400 parts of diethylmalonate at 160°C for 1 hour, and the alcohol formed by the reaction is allowed to distill off. Thereafter the reaction mass is cooled to 80°C, and 500 parts of alcohol are added. After cooling the dixylidide is sucked off, and the alcohol solution with malonic ester monoxylidide is poured into 2,000 parts of water. The monoxylidide precipitates, is filtered off and washed with water, and recrystallized in diluted alcohol. Nitrosation thereafter takes place by dissolving the dried monoxylidide in chloroform and by introducing nitrosyl chloride at 0°C until the nitrosation is completed. The isonitrosomalonic ester xylidide is filtered off and dried. Thereafter the reduction takes place with zinc powder and formic acid at 90°-100°C.
The formic acid is distilled off, and the remainder dissolved in warm benzene and washed with a bicarbonate solution to a neutral reaction. After the benzene has been distilled off, the aminomalonic ester xylidide is obtained. This is treated with an equal quantity of sodium ethylate and boiled with twice the theoretical quantity of tetramethylene bromide in absolute alcohol. After 6 hours of boiling, the sodium bromide formed is separated, and the mixture is steamdistilled in order to remove the excess of tetramethylene bromide. The remaining oil, which mainly consists of deltabromobutylaminomalonic ester xylidide is separated from the water and boiled with 3 parts of concentrated hydrochloric acid for 3 hours. Thereafter carbonfiltering and evaporation to dryness under vacuum takes place. The residue is dissolved in water, and the pH adjusted with sodium hydroxide to 5.5. The solution is extracted twice with ether, and the water is made strongly alkaline with sodium hydroxide.
The oil precipitates and is crystallized after a time. The crystals are separated and dried under vacuum. The pipecolyl-2,6-xylidide produced is alkylated by boiling for 10-20 hours with 0.6 part n-butylbromide in an n-butanol solution in the presence of 0.5 part potassium carbonate. The potassium carbonate is filtered off and the butanol is distilled off in vacuum. The residue is dissolved in diluted hydrochloric acid and carbon treated, after which the base is precipitated with sodium hydroxide in the form of white crystals, which are filtered off and washed with water. The base obtained, which consists of N-n-butyl-pipecolyl-2,6-xylidide is sufficiently pure for the production of salts.

Brand nameMarcaine (Hospira); Sensorcaine (AstraZeneca).
Therapeutic FunctionLocal anesthetic
Biological Activitybupivacaine hydrochloride is a local anaesthetic drug belonging to the amino amide group.bupivacaine hydrochloride is an effective local anesthetic agent. it has a rapid onset time, a high frequency of surgical anesthesia, a long duration, and a low incid
bupivacaine hydrochloride Preparation Products And Raw materials
Raw materialsZINC-->Nitrosyl chloride-->4-Bromo-2,6-dimethylaniline-->1-Bromobutane-->Diethyl malonate-->Formic acid
Forskolin CGS 21680A ESI 09 S3I-201 Selumetinib H-89 DIHYDROCHLORIDE HYDRATE 2',6'-Pipecoloxylidide Bupivacaine hydrochloride Bupivacaine

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