ZM 306416

ZM 306416 Basic information
Product Name:ZM 306416
Synonyms:ZM 306416 HYDROCHLORIDE;4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE;4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy-;ZM306416/ZM-306416;CB 676475;CB676475;CB-676475;ZM 213689 DisodiuM Salt (MeropeneM iMpurity) (Mixture of double bond isoMers)
CAS:690206-97-4
MF:C16H13ClFN3O2
MW:333.74
EINECS:
Product Categories:Inhibitors;Angiogenesis and Metastasis
Mol File:690206-97-4.mol
ZM 306416 Structure
ZM 306416 Chemical Properties
Melting point >161°C (dec.)
Boiling point 434.1±45.0 °C(Predicted)
density 1.389±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol (Slightly), Water (Sparingly)
pka5.49±0.30(Predicted)
form Off-white solid.
color Light Orange to Brown
Stability:Hygroscopic
Safety Information
MSDS Information
ZM 306416 Usage And Synthesis
UsesZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively.
UsesZM 306416 an inhibitor of tyrosine kinase RTK signaling pathway involved in anti-cancer agents. Anti-tumor, anti-metastatic agent.
UsesThe major metabolite of Meropenem (M225620) - a carbapenem antibiotic - in plasma and urine. This metabolite existed as a mixture of 1-pyrroline and its 2-pyrroline isomer, and the coexistence of the two isomers at equilibrium in aqueous solutions was observed by NMR.
DefinitionChEBI: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine is a member of quinazolines.
Biological Activityzm 306416 is a selective inhibitor of vegfr with ic50 value of 0.67μm [1]. it is also reported that zm 306416 inhibits egfr with ic50 value less than 10 nm [2].vascular endothelial growth factor receptor (vegfr) is a key element of the extracellular matrix(ecm) and plays an important role in angiogenesis cooperating with its ligand vegf. several studies have demonstrated that vegfrs expressed in liquid and solid tumor cells, such as nsclc, melanoma, prostate cancer, leukemia, mesothelioma, and breast cancer and are being regarded as a promising target in clinical [3].zm 306416 is a potent vegfr inhibitor and has a different selectivity with other reported vegfr inhibitors. using a549-egfrb cells for egfrb assay revealed that zm 306416 exhibited inhibitory activity on vegfr with ic50 value of 670 nm [1]. when tested with human thyroid follicular cells, zm 306416 treatment exhibited function on reducing vegfr2 phosphorylation and inhibiting endogenous, steady-state levels of p42/44 mapk phosphorylation [4].
targetVEGFR1
references1. antczak, c., et al., a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function: implications in drug discovery. j biomol screen, 2012. 17(7): p. 885-99.2. choi kj, baik ih, ye sk et al. molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull. 2015;38(7):986-91. 3. choi, k.j., et al., molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull, 2015. 38(7): p. 986-91.4. susarla, r., j.c. watkinson, and m.c. eggo, regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling. mol cell endocrinol, 2012. 351(2): p. 199-207.
ZM 306416 Preparation Products And Raw materials
Vandetanib AAL-993 ZM 230487 N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE ABT 263 ZM 241385 ZM306416 ZM 39923 HCl ZM 336372 5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL CP-673451 Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- Axitinib Y27632 (hydrochloride) ZM 447439 ZM 323881 hydrochloride Everolimus ZM 306416

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