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| | MURISTERONE A Basic information |
| Product Name: | MURISTERONE A | | Synonyms: | 2B,3B,5A,11A,14,20,22-HEPTAHYDROXY-5B-7-CHOLESTEN-6-ONE;2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTAHYDROXY-5BETA,7-CHOLESTEN-6-ONE;2BETA,3BETA,5BETA,11ALPHA,14ALPHA,20R,22R-HEPTAHYDROXYCHOLEST-7-EN-6-ONE;5B, 7-CHOLESTENE-2B,3B,5A,11A,14,20,22-HEPTOL-6-ONE;5BETA,7-CHOLESTENE-2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTOL-6-ONE;MurA, 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one;(22R)-2β,3β,5,11α,14,20,22-Heptahydroxy-5β-cholest-7-en-6-one;Ecdysonic sterol | | CAS: | 38778-30-2 | | MF: | C27H44O8 | | MW: | 496.63 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 38778-30-2.mol |  |
| | MURISTERONE A Chemical Properties |
| Boiling point | 707.2±60.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | solid | | pka | 11.78±0.70(Predicted) | | color | white |
| | MURISTERONE A Usage And Synthesis |
| Description | Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies. | | Uses | Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells. | | Biological Activity | Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. | | storage | +4°C |
| | MURISTERONE A Preparation Products And Raw materials |
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