| Description | Bromadiolone is used to control rodents around buildings,
inside transport vehicles and sewers. It is often formulated as
meal bait, rat and mouse bait ready-to-use place packs, paraffinized
pellets and blocks. |
| Chemical Properties | Bromadiolone is white to off-white (yellowish)
powder. |
| Occurrence | Boldo is an evergreen found in Chile, Peru, and Morocco. |
| Uses | Rodenticide. |
| Uses | Bromadiolone is used for the control of rats and mice. |
| Uses | Bromadiolone is an anticoagulant rodenticide used on non-crop areas. |
| Definition | ChEBI: Bromadiolone is a diarylheptanoid. |
| General Description | Yellowish powder. Used as an anticoagulant rodenticide. |
| Health Hazard | The compound is toxic by oral exposure. |
| Fire Hazard | (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated to decomposition, Bromadiolone emits toxic fumes of bromine containing compounds. |
| Agricultural Uses | Rodenticide: Bromadiolone is used as an anticoagulant rodenticide
and used as bait for rodent control against house mice,
roof rats and warfarin-resistant Norway rats. It is also authorized
by USDA for use in official establishments operating
under the Federal meat, poultry, shell egg grading
and egg products inspection program. |
| Trade name | BOLDO®; BOOT HILL®; BROMONE®;
CANADIEN 2000®; CONTRAC®; HAWK®; LM-
637®; MAKI®; RAT ARREST®; RAT FREE®;
RATIMUS®; RENTOKIL DEADLINE®; SLAYMOR®;
SUPER-CAID®; SUPER-ROZOL®; SUP'ORATS®;
TERMUS® |
| Potential Exposure | Bromadiolone is used as an anticoagulant
rodenticide. It is bait for rodent control used against
house mice, roof rats, warfarin-resistant Norway rats. It is
also authorized by USDA for use in official establishments
operating under the federal meat, poultry, shell egg grading,
and egg products inspection program. May be used as a drug. |
| Environmental Fate | Bromadiolone belongs to second generation of long-acting
anticoagulant rodenticide. It acts by interfering with the
prothrombin synthesis by blocking the regeneration of vitamin
K dependant proteins in the liver and thereby disrupting the
clotting mechanisms and increasing the tendency to hemorrhages
and subsequent death. |
| Metabolic pathway | Metabolism in the rat is very slow and products other than a conjugate of
the parent compound have not been identified. Biodegradation in soil and
plants has not been reported. |
| Shipping | UN3027 Coumarin derivative pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.
UN3026 Coumarin derivative pesticides, liquid, toxic,
Hazard Class: 6.1; Labels: 6.1—Poisonous materials. |
| Toxicity evaluation | Bromadiolone may be released into the environment
through various waste streams and its use.
If released to air, it will exist in the particulate phase in the
ambient atmosphere and will be removed by dry and wet deposition. In soil, it is not persistent under aerobic conditions
(half-life is 14 days) and is usually immobile except in soils of
low organic matter and clay, such as sand.
When released to water, it adsorbs to suspended solids
and sediment. Bromadiolone is stable to hydrolysis at pH 5,
7, and 9. Two major degradates, [1,3-diphenyl-5(40-bromobiphenyl)
pentane-1-ol] and [1,3-diphenyl-5(40-bromobiphenyl)
pentane-1,5-diol], are detected in the aerobic soil
metabolism study.
Bromadiolone is bioaccumulated in edible and nonedible
tissues in bluegill sunfish at the bioaccumulation concentration
factors of 160X and 1658X. It was also detected in birds. |
| Degradation | Bromadiolone is a stable compound. It is a weak acid. |
