ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Thiophene compounds 2,5-Dichlorothiophene

2,5-Dichlorothiophene

2,5-Dichlorothiophene Basic information
Product Name:2,5-Dichlorothiophene
Synonyms:DICHLOROTHIOPHENE;2,5-DICHLOROTHIOPHENE;2,6-DICHLOROTHIOPHENE;2,5-dichloro-thiophen;thiophene,2,5-dichloro-;2,5-Dichlorothiophenene;2,5-Dichlorothiophene,97%;5-chloro-2-thienyl chloride
CAS:3172-52-9
MF:C4H2Cl2S
MW:153.03
EINECS:221-638-8
Product Categories:Heterocycle-oher series;Halogenated Heterocycles;Thiophenes;Organics;Heterocyclic Building Blocks;ThiophenesBuilding Blocks;Thiophene&Benzothiophene;Miscellaneous;Thiophens
Mol File:3172-52-9.mol
2,5-Dichlorothiophene Structure
2,5-Dichlorothiophene Chemical Properties
Melting point -41--40°C
Boiling point 162 °C (lit.)
density 1.442 g/mL at 25 °C (lit.)
refractive index 1.561-1.563
Fp 59 °C
storage temp. 2-8°C
form liquid
Specific Gravity1.442
color Colorless to Light yellow to Light orange
BRN 109887
CAS DataBase Reference3172-52-9(CAS DataBase Reference)
NIST Chemistry ReferenceThiophene, 2,5-dichloro-(3172-52-9)
EPA Substance Registry SystemThiophene, 2,5-dichloro- (3172-52-9)
Safety Information
Hazard Codes T+,Xn
Risk Statements 40-26/27/28-36/37/38-20/21/22
Safety Statements 45-36/37-28A-36-26
RIDADR 2929
WGK Germany 3
TSCA T
HazardClass 6.1
PackingGroup II
HS Code 29349990
MSDS Information
ProviderLanguage
2,5-Dichlorothiophene English
ACROS English
ALFA English
2,5-Dichlorothiophene Usage And Synthesis
Chemical Propertiesclear colorless to slightly yellow liquid
Uses2,5-Dichlorothiophene is mainly used as a pharmaceutical intermediate. It is used in the synthesis of 3,4-disubstituted thiophenes.
Synthesis Reference(s)Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4
2,5-Dichlorothiophene Preparation Products And Raw materials
Preparation ProductsLornoxicam-->Brinzolamide-->2,5-Dichlorothiophene-3-sulfonyl chloride-->5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID-->5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE-->2,5-Dichlorothiophene-3-sulfonamide-->5-CHLORO-2-THIOPHENECARBOXYLIC ACID HYDRAZIDE-->2,5-DICHLORO-3,4-DINITROTHIOPHENE-->2,3,5-TRICHLOROTHIOPHENE-->ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE-->3-Acetyl-2,5-dichlorothiophene-->2-Chlorothiophene-->3,4-Dichlorothiophene-->5-CHLORO-2-THIOPHENECARBONITRILE-->2,5-dichloro-3-(chloromethyl)thiophene
3,4-DIBROMO-2,5-DICHLOROTHIOPHENE N3-(3-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}propyl)-2,5-dichlorothiophene-3-sulfonamide N3-imino(4-pyridyl)methyl-2,5-dichlorothiophene-3-sulfonamide 2,5-Dichlorothiophene-3-carbaldehyde N3-(5-methylisoxazol-3-yl)-2,5-dichlorothiophene-3-carboxamide N3-[3-(dimethylamino)propyl]-2,5-dichlorothiophene-3-sulfonamide 2,4-Dichlorothieno[2,3-d]pyrimidine 2,5-Dichlorothiophene-3-sulfonyl chloride N3-di(methylthio)methylidene-2,5-dichlorothiophene-3-sulfonamide 3-({[amino(imino)methyl]amino}sulfonyl)-2,5-dichlorothiophene 3-BROMO-2,5-DICHLOROTHIOPHENE N3-[2-(2,4-dichlorophenoxy)phenyl]-2,5-dichlorothiophene-3-carboxamide 3,3'-bis[2,5-dichlorothiophene] N3-(5-methylisoxazol-3-yl)-2,5-dichlorothiophene-3-sulfonamide 2,3-DICHLOROTHIOPHENE N3-(4-bromo-1-methyl-1H-pyrazol-3-yl)-2,5-dichlorothiophene-3-sulfonamide 2,5-DICHLOROTHIOPHENE-3-SULFONAMIDE,2,5-Dichlorothiophene-3-sulfonamide ,97% 2,5-DICHLOROTHIOPHENE-3-CARBOXYLIC ACID
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