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| | (-)-Donepezil Basic information |
| Product Name: | (-)-Donepezil | | Synonyms: | 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, (2S)-;S-(-)-DONEPEZIL | | CAS: | 142057-80-5 | | MF: | C24H29NO3 | | MW: | 379.49 | | EINECS: | | | Product Categories: | | | Mol File: | 142057-80-5.mol |  |
| | (-)-Donepezil Chemical Properties |
| Melting point | 108-110°C | | Boiling point | 527.9±50.0 °C(Predicted) | | density | 1.141±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | | pka | 8.84±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | (-)-Donepezil Usage And Synthesis |
| Uses | (-)-Donepezil is an isomer of Donepezil (D531750), a nootropic, acting as an inhibitor of acetylcholinesterase. | | Definition | ChEBI: Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. It contains a (R)-donepezil and a (S)-donepezil. It is a conjugate base of a donepezil (1+). |
| | (-)-Donepezil Preparation Products And Raw materials |
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