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| | POLYPHYLLIN D Basic information |
| | POLYPHYLLIN D Chemical Properties |
| Melting point | >245°C (dec.) | | density | 1.40 | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) | | pka | 12?+-.0.70(Predicted) | | form | Solid | | color | White |
| | POLYPHYLLIN D Usage And Synthesis |
| Description | Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model. | | Uses | Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers. |
| | POLYPHYLLIN D Preparation Products And Raw materials |
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