AZATADINE MALEATE (200 MG)

AZATADINE MALEATE (200 MG) Basic information
Product Name:AZATADINE MALEATE (200 MG)
Synonyms:11h-benzo(5,6)cyclohepta(1,2-b)pyridine,5,6-dihydro-11-(1-methyl-4-piperidylid;6,11-dihydro-11-(1-methyl-4-piperidylidene)5h-benzo(5,6)cyclohepta(1,2-b)pyr;azatadinedimaleate;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2);azatadinemaleate;idinedimaleate;idulian;optimine
CAS:3978-86-7
MF:C28H30N2O8
MW:522.5464
EINECS:223-615-8
Product Categories:
Mol File:3978-86-7.mol
AZATADINE MALEATE (200 MG) Structure
AZATADINE MALEATE (200 MG) Chemical Properties
Melting point 152-154°
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Safety Information
HS Code 2933399090
MSDS Information
AZATADINE MALEATE (200 MG) Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorIdulian,Unilabo,France,1968
UsesAntihistaminic.
DefinitionChEBI: The dimaleate salt of azatadine.
Manufacturing ProcessPreparation of 4-aza-5-(N-methyl-4-piperidyl)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene-5-ol: Add 17.4 g of N-methyl-4-chloropiperidine to a stirred mixture containing 3.2 g of magnesium, 20 ml of anhydrous tetrahydrofuran, 1 ml of ethyl bromide and a crystal of iodine. Reflux for two hours, cool to 30-35°C and add a solution of 13 g of 4-aza-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene-5-one in 25 ml of tetrahydrofuran. Stir for five hours, remove the solvent by distillation in vacuum and add 250 ml of ether. Add 100 ml of 10% ammonium chloride solution and extract the mixture with chloroform. Concentrate the chloroform solution to a residue and recrystallize from isopropyl ether obtaining 20 g of the carbinol, MP 173-174°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene: Heat 5.4 g of the carbinol and 270 g of polyphosphoric acid for 12 hours at 140-170°C. Pour into ice water and make alkaline with sodium hydroxide. Extract with ether. Dry ether solution and concentrate to a residue. Crystallize from isopropyl ether, MP 124-126°C.
Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5Hdibenzo[ a,d]cycloheptene dimaleate: To a solution containing 4.3 g of 4-aza- (N-methyl-4-piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene in 55 ml of ethyl acetate, add a solution of 3.45 g of maleic acid dissolved in ethyl acetate. Filter the resulting precipitate and recrystallize the desired product from an ethyl acetate-methanol mixture to yield 4-aza-5-(N-methyl-4- piperidylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene dimaleate, MP 152-154°C.

Brand nameOptimine (Schering);Verban.
Therapeutic FunctionAntihistaminic
General DescriptionAzatadine maleate, 6,11-dihydro-11-(l-methyl-4-piperidylidene)-5H-benzo-[5,6]cyclo-hepta(1,2-b]pyridine maleate (1:2) (Optimine), is a potent,long-acting antihistaminic with antiserotonin activity. Inearly testing, azatadine exhibited more than three times thepotency of chiorpheniramine in the isolated guinea pigileum screen and more than seven times the oral potency ofchlorpheniramine in protection of guinea pigs against a doublelethal dose of intravenously administered histamine.
AZATADINE MALEATE (200 MG) Preparation Products And Raw materials
Raw materialsMagnesium-->Bromoethane-->Polyphosphoric acid-->Maleic acid-->4-Chloropiperidine hydrochloride
5-Azacytidine

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