Xylazine Hydrochloride

Xylazine Hydrochloride Basic information
Product Name:Xylazine Hydrochloride
Synonyms:2-[2,6-DIMETHYLPHENYLAMINO]-4H-5,6-DIHYDROTHIAZINE HYDROCHLORIDE;2-[(2,6-DIMETHYLPHENYL)AMINO]-5,6-DIHYDRO-4H-1,3-THIAZINE HYDROCHLORIDE;2-(2,6-DIMETHYLPHENYLAMINO)-5,6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE;XYLAZINE HYDROCHLORIDE VETRANAL, 100 MG;XYLAZINE HYDROCHLORIDE, USP STANDARD;XYLAZINE HYDROCHLORIDE, EP STANDARD;XYLAZINE HYDROCHLORIDE, MM(CRM STANDARD);XYLAZINE HYDROCHLORIDE, IMP. A (EP): 2,6-DIMETHYLANILINE MM(CRM STANDARD)
CAS:23076-35-9
MF:C12H17ClN2S
MW:256.79
EINECS:245-417-0
Product Categories:Other APIs;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;23076-35-9
Mol File:23076-35-9.mol
Xylazine Hydrochloride Structure
Xylazine Hydrochloride Chemical Properties
Melting point 150-164?C (dec.)
storage temp. 2-8°C
solubility ≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O
form neat
color White to Almost white
Water Solubility Soluble in water
Merck 14,10080
BRN 6448471
InChIInChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
InChIKeyQYEFBJRXKKSABU-UHFFFAOYSA-N
SMILESN(C1SCCCN=1)C1C(=CC=CC=1C)C.Cl
CAS DataBase Reference23076-35-9(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 26-36/37/39-45
RIDADR 2811
WGK Germany -
RTECS XJ0776350
HazardClass 6.1(b)
PackingGroup III
HS Code 29349990
Toxicitydog,LD50,intramuscular,47mg/kg (47mg/kg),Clinical Toxicology. Vol. 15, Pg. 281, 1979.
MSDS Information
ProviderLanguage
SigmaAldrich English
Xylazine Hydrochloride Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesXylazine hydrochloride is α2 class of adrenergic receptor agonist. As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. It is a clonidine analoque. It acts on presynaptic and postsynaptic receptors of the central and peripheral nervous systems. It is used as a sedative, analgesic, muscle relaxant. It is also used to anesthetize rats/mice.
DefinitionChEBI: Xylazine hydrochloride is the hydrochloride salt of xylazine. It is used as a sedative, analgesic, and muscle relaxant in veterinary medicine. It has a role as an alpha-adrenergic agonist, an analgesic, an emetic, a muscle relaxant and a sedative. It contains a xylazine(1+).
Brand nameRompun (Bayer Animal Health).
Biological ActivityXylazine Hydrochloride is a strong agonist of α2-adrenoceptor [1].xylazine hcl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mm) [2]. in the analgesic testing, xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. in addition, xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the ic50 value of 18nm. furthermore, xylazine has displayed a potent specific [3h]-dihydromorphine binding inhibition with the ic50 value of 8μm in opiate receptor binding test [1].
Biochem/physiol ActionsXylazine is used as a sedative in goats as it is safe, active and a cheap drug. It is a centrally acting drug, which exhibits muscle relaxant and analgesic properties.
Veterinary Drugs and TreatmentsXylazine Hydrochloride is approved for use in dogs, cats, horses, deer, and elk. It is indicated in dogs, cats, and horses to produce a state of sedation with a shorter period of analgesia, and as a preanesthetic before local or general anesthesia. Because of the emetic action of xylazine in cats, it is occasionally used to induce vomiting after ingesting toxins.
Clinical UseXylazine Hydrochloride is an alpha-2 agonist with sedative, analgesic, and muscle relaxant properties. It is approved for use in dogs,cats,horses,deer,and elk. This agent causes vomiting in a large percentage of cats and in some dogs. Xylazine is antagonized by yohimbine. It produces effective analgesia in horses and is often used for treating the pain associated with colic and for sedation for minor procedures.It is also used in combination with ketamine for short-term feld procedures in horses,such as castration and suturing of extensive wounds,because this combination usually produces 15 to 20 minutes of recumbency. Extralabel use of xylazine for cesarean sections in cattle and other surgical procedures is common. Xylazine Hydrochloride is used in cats and dogs as a tranquilizer and in combination with other injectable agents for surgical procedures.
references[1] s. browning, d.lawrence1, a.livingston & b.morris. interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] colić m1, cupić v, pavicić l, vucević d, varagić vm. xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. methods find exp clin pharmacol. 2000 sep;22(7):557-62.
Xylazine Hydrochloride Preparation Products And Raw materials
Phenylhydrazine hydrochloride PAZUFLOXACIN MESYLATE Xylometazoline hydrochloride XYLAZINE IMPURITY C Thiamethoxam Methylprednisolone acetate XYLAZINE IMPURITY E Fluanisone XYLAZINE HYDROCHLORIDE A2 ADRENOCEPTOR A GONI Ethylmagnesium bromide Raspberry Ketone PROPOFOL RELATED COMPOUND A (25 MG) (3,3'-5,5'-TETRAISOPROPYLDIPHENOL) KETAMINE HYDROCHLORIDE/XYLAZINE HYDROCHLORIDE,Ketamine hydrochloride/xylazine hydrochloride solution Xylazine Hydrochloride Propofol PROPOFOL RELATED COMPOUND B (50 MG) (2,6-DIISOPROPYLBENZOQUINONE) PROPOFOL IMPURITY J BENZTHIAZIDE

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