Polysorbate 20

Polysorbate 20 Basic information
Description References
Product Name:Polysorbate 20
Synonyms:Polisorbate 20- PS 20;Tween 20 (Trademark of ICI America, Inc.);Tween 20 ;Tween 20 1LT;Twain 20;TWEEN(R) 20 Vetec(TM) reagent grade, 40%;ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE;TWEEN 20 ELECTROPHORESIS GRADE
CAS:9005-64-5
MF:C26H50O10
MW:522.6692
EINECS:500-018-3
Product Categories:detergent;Functional Materials;Nonionic Surfactants;Surfactants;Alphabetical Listings;Flavors and Fragrances;Ester Ether Type (Surfactants);Biochemistry;Nonionic Surfactants (for Biochemistry);Surfactants (for Biochemistry);O-P;9005-64-5
Mol File:9005-64-5.mol
Polysorbate 20 Structure
Polysorbate 20 Chemical Properties
Melting point 98.9 °C (decomp)
Boiling point 100 °C
density 1.11 g/mL at 20 °C
vapor pressure <1.4 hPa (20 °C)
FEMA 2915 | POLYSORBATE 20
refractive index n20/D 1.468(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility 100 g/L
form viscous liquid
color Amber
Specific Gravity1.090~1.130 (20/20℃)
Odormild alcohol odor
PH6-8 (50g/l, H2O, 20℃)
PH Range7
Odor Typealcoholic
Water Solubility 100 g/L
Hydrophilic-Lipophilic Balance (HLB)16.7
Stability:Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry SystemPolysorbate 20 (9005-64-5)
Safety Information
Hazard Codes Xi
Risk Statements 22-36/37/38-37/38-41
Safety Statements 24/25-36/37/39-36-26
WGK Germany 1
RTECS TR7400000
10-23
TSCA Yes
HS Code 34021300
Hazardous Substances Data9005-64-5(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 38900 mg/kg
MSDS Information
ProviderLanguage
Tween 20 English
ACROS English
SigmaAldrich English
ALFA English
Polysorbate 20 Usage And Synthesis
DescriptionTween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.
Referenceshttps://en.wikipedia.org/wiki/Polysorbate_20
http://www.organic-creations.com/thickeners-stabilizers/599-polysorbate-20
Chemical PropertiesPolysorbate 20 is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides. It has a faint, characteristic odor and a warm, somewhat bitter taste.
Chemical PropertiesYellow liquid
UsesUsed for solubilizing membrane proteins during isolation and purification.Polysorbate 20 is used as a wetting agent in flavored mouth drops. It acts as a washing agent in Western blots and ELISAs and prevents antibody binding. It is a solubilizing agent of membrane proteins. In pharmaceutical chemistry, it is used as an excipient to stabilize emulsions and suspensions. Further, it is used as a dispersing agent, stabilizer, lubricator and also used in creams, salves, ointments, protective creams, balms, pomades, lipsticks, mascaras and glosses.
Usespolysorbate 20 is a solubilizer, emulsifier, viscosity modifier, and stabilizer of essential oils in water.
Preparationpolysorbate 20 is prepared by condensing the partial esters of sorbitol and its anhydrides with ethylene oxide to effect an oxyethylene copolymerization at the free hydroxyl groups.
DefinitionChEBI: Polysorbate 20 (Tween 20) is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group. It is a surfactant and emulsifier used in cleaners and personal care products.
Brand nameTween 20 (ICI Americas).
General DescriptionPolysorbate 20 is a hydrophilic nonionic surfactant generally used as emulsifiers, dispersing agent and solubilizer.
Health effectsPolysorbate 20 was a skin irritant in dermatitis patients but was reported not to induce irritant responses when applied to the intact skin of health volunteers. It produced, at worst, minimal irritation in the eyes of rabbits. Only a small number of cases of skin sensitization have been reported in humans, although a moderate to strong sensitizing potential was seen in guinea-pigs treated by intradermal injection.
Flammability and ExplosibilityNonflammable
Safety ProfileModerately toxic by intravenous route. Mddly toxic by ingestion. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Polysorbate 20 Preparation Products And Raw materials
Raw materialsETHYLENE OXIDE-->Sodium ethoxide
Tween 60 polysorbate 40 Polyethylene Glycol Monocetyl Ether POLYETHYLENE GLYCOL MONOOLEYL ETHER Span 80 Cremophor EL Food emulgent Bitumen emulsifier Span 60 Span 20 Polysorbate 20 Polyoxyethylene lauryl ether alkyl phenyl polyoxyethylene ether Polyethylene Glycol Triton X-100 Sorbitol -60 TWEEN-60 EMULSIFIER

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