5-Fluoro-2-oxindole

5-Fluoro-2-oxindole Basic information

Product Name:	5-Fluoro-2-oxindole
Synonyms:	5-Fluoroindole-2-One;5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXINDOLE;5-FLUORO-2-OXYINDOLE;5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Fluorooxindole 98%;5-Fluorooxindole98%;5-FLUROOXINDOLE
CAS:	56341-41-4
MF:	C8H6FNO
MW:	151.14
EINECS:	638-803-9
Product Categories:	Fluorinated heterocyclic series;Indoles and derivatives;Indole/indoline/oxindole;Indole and Indoline;Heterocycles;Aromatics Compounds;Halides;Pyrroles & Indoles;ketone;Sunitinib;Intermediate of sunitinib malate;Aromatics;Pyrroles & Indoles;Boronic Acid;INDOLE;blocks;FluoroCompounds;IndolesOxindoles;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Indoles;Intermediates;56341-41-4
Mol File:	56341-41-4.mol

5-Fluoro-2-oxindole Chemical Properties

Melting point	143-147 °C (lit.)
Boiling point	307.2±42.0 °C(Predicted)
density	1.311±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.99±0.20(Predicted)
form	Powder or Crystalline Powder
color	White to pale brown
InChIKey	DDIIYGHHUMKDGI-UHFFFAOYSA-N
CAS DataBase Reference	56341-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38-34
Safety Statements	22-24/25-45-36/37/39-27-26
WGK Germany	3
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT, KEEP COLD
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

5-Fluoro-2-oxindole Usage And Synthesis

Chemical Properties	Light Yellow Crystalline
Uses	5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.
Application	5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.
Preparation	synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.

5-Fluoro-2-oxindole Preparation Products And Raw materials

Raw materials

Sodium hydride-->Iron-->Dimethyl sulfoxide-->Dimethyl malonate-->Lithium chloride-->2,4-Difluoronitrobenzene-->1-hydroxy-3H-indol-2-one-->Ethyl iodoacetate-->4-FLUOROISONITROSOACETANILIDE-->5-Fluoro-3-hydrazonoindolin-2-one-->2-(2-aMino-5-fluorophenyl)acetohydrazide-->5-Fluoro-2-nitrophenylacetic acid-->Benzeneacetic acid, 5-fluoro-2-nitro-, Methyl ester-->5-Fluoroisatin-->4-Fluoroacetanilide-->ETHYL (METHYLTHIO)ACETATE-->tert-Butyl Hypochlorite

Preparation Products

5-FLUORO-6-CHLORO ISATIN Fluorine Dehydroepiandrosterone Indometacin Fluorochloridone Indole-3-butyric acid 5-Fluoro-2-oxindole cis-Octahydroisoindole 1-(2,6-Dichlorophenyl)indolin-2-one Fluridone Naringin dihydrochalcone Oxindole 4-Fluoroacetophenone 5-Fluoroindole Isophorone 5-FLUORO-3-(4-HYDROXY-BUTYL)-1,3-DIHYDRO-INDOL-2-ONE Indole-3-acetic acid 4'-(Trifluoromethyl)acetophenone

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