3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Basic information
Product Name:3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
Synonyms:3,3-Difluoropyrrolidine hydrochloride;3,3-Difluoropyrrolidine hydrochloride 97%;GOSO-005;cis-1-Methyl-2-oxo-1,2-dihydro-quinoline-5-carboxylic acid;3,3-DIFLUOROPYRROLIDINE HCL;3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 3,3-difluoro-, hydrochloride (1:1);1-Aza-3,3-difluorocyclopentane
CAS:163457-23-6
MF:C4H7F2N.ClH
MW:143.56
EINECS:626-850-8
Product Categories:Fluorinated Building Blocks;Halogenated Heterocycles;Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;pharmacetical;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycles;Miscellaneous Reagents;C4 to C10;Chemical Synthesis;Pyrrolidines;PyrrolidinesHeterocyclic Building Blocks
Mol File:163457-23-6.mol
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Structure
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Chemical Properties
Melting point 128-130°C
storage temp. Inert atmosphere,Room Temperature
form solid
color White to off white
Sensitive Hygroscopic
InChIKeyYYVPZQADFREIFR-UHFFFAOYSA-N
CAS DataBase Reference163457-23-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39
WGK Germany 3
Hazard Note Irritant
HazardClass IRRITANT, HYGROSCOPIC
HS Code 29339900
MSDS Information
ProviderLanguage
ALFA English
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Usage And Synthesis
Chemical PropertiesBeige solid
Uses3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:
  • Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
  • Dual leucine zipper kinase (DLK) inhibitors.

It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.
3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials1-BOC-3,3-DIFLUOROPYRROLIDINE
Preparation Productstert-Butyl 4-(3,3-difluoropyrrolidin-1-yl)piperidine-1-carboxylate
(8aS)-7,7-difluorooctahydropyrrolo[1,2-a]pyrazine TETRAFLUOROSUCCINIMIDE N-BOC-4,4-difluoro-L-proline BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE BOC-D-PRO(4,4-DIFLUORO) tert-butyl (2S)-2-cyano-4,4-difluoropyrrolidine-1-carboxylate 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE 4,4-DIFLUORO-D-PROLINAMIDE HYDROCHLORIDE 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE 1-CBZ-3,3-DIFLUOROPYRROLIDINE BOC-4,4-DIFLUORO-L-PROLINAMIDE 1-BOC-3,3-DIFLUOROPYRROLIDINE (2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid 4,4-DIFLUORO-N-METHYL-N-METHOXY-L-PROLINAMIDE HCL FMOC-D-PRO(4,4-DIFLUORO) 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE

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