Methylboronic acid

Methylboronic acid Basic information

Product Name:	Methylboronic acid
Synonyms:	METHYLBORON DIHYDROXIDE;METHYLBORONIC ACID;METHANEBORONIC ACID;CH5BO2;dihydroxy-methyl-borane;Methylboron dihydroxide, GLC Grade;Methylboronic acid ,98%;Methylboranic acid
CAS:	13061-96-6
MF:	CH5BO2
MW:	59.86
EINECS:	629-203-8
Product Categories:	Piperidines ,Piperazines ,Homopiperidines;Alkyl;Substituted Boronic Acids;API intermediates;Boronic acid;Organoborons;CHIRAL CHEMICALS
Mol File:	13061-96-6.mol

Methylboronic acid Chemical Properties

Melting point	91-94 °C (lit.)
Boiling point	141.7±23.0 °C(Predicted)
density	0.965±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO, Water
form	Crystalline Powder
pka	9.97±0.43(Predicted)
color	White to off-white
Water Solubility	Soluble in water.
Sensitive	Hygroscopic
BRN	1731087
InChI	InChI=1S/CH5BO2/c1-2(3)4/h3-4H,1H3
InChIKey	KTMKRRPZPWUYKK-UHFFFAOYSA-N
SMILES	CB(O)O
CAS DataBase Reference	13061-96-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	3-10
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Methylboronic acid Usage And Synthesis

Chemical Properties	White to light yellow crystal powde
Uses	suzuki reaction
Uses	Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.
Uses	Methylboronic acid can be used as a reagent: In the palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings. In the microwave-heated heterogeneous palladium (Pd)-catalytized reactions. In ruthenium (Ru)-catalyzed silylation reactions To prepare bis(aminotropone) titanium (Ti) catalysts for ethylene polymerizations. In the enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts. To prepare common building blocks for pharmaceuticals and agrochemicals. To prepare chrysin analogs by Suzuki-Miyaura coupling reactions. To prepare casein kinase I inhibitors. In the divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery. In the synthesis of unsymmetrical monosulfides from disulfides via copper-catalyzed coupling with boronic acids. In a palladium-catalyzed coupling with enol tosylates. For derivatizing many carbohydrates and biologically active compounds for GLC analysis.

Methylboronic acid Preparation Products And Raw materials

Raw materials

dimethylammonium iodide-->Dimethylamine-->Water

Preparation Products

2-Nitrophenylboronic acid-->Guaiazulene-->1H-Indole-2,3-dione, 5-methyl-7-(trifluoromethyl)--->Diethyl isopropylmalonate-->3-BroMo-5-fluoro-2-Methyl-pyridine-->CHAMAZULEN-->3-Amino-5-chloropicoline-->Ethanone, 1-[4-(methylamino)phenyl]- (9CI)-->2-METHYLBENZO[B]THIOPHENE-->4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester-->N-Phenylmethanesulfonamide-->5-BROMO-2-METHYLINDOLE-->3-Amino-2-picoline-->4-CHLORO-2-METHYLQUINOLINE

Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid Methylboronic acid 3-Carboxyphenylboronic acid Zinc borate 3-Methoxyphenylboronic acid Stearic acid Folic acid DICHLOROMETHYLDIISOPROPOXYBORANE Phenylboronic acid 4-Fluorobenzeneboronic acid Allylboronic acid pinacol ester 1-stearylboronic acid 1-Naphthylboronic acid 3-Chloro-4-fluorophenylboronic acid BUTYLDIISOPROPOXYBORANE Citric acid

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