Diethyl 1,1-cyclobutanedicarboxylate

Diethyl 1,1-cyclobutanedicarboxylate Basic information

Product Name:	Diethyl 1,1-cyclobutanedicarboxylate
Synonyms:	DIETHYL 1,1-CYCLOBUTANEDICARBOXYLATE;1,1-Cyclobutanedicarboxylic Acid 1,1-Diethyl Ester;NSC 9017;1,1-Bis(ethoxycarbonyl)cyclobutane;1,1-Dicarboxylic acid cyclobutane diethylester;1,1-CYCLOBUTANEDICARBOXYLIC ACID DIETHYL ESTER;1,1-DICARBOETHOXYCYCLOBUTANE;AKOS BBS-00006459
CAS:	3779-29-1
MF:	C10H16O4
MW:	200.23
EINECS:	223-239-4
Product Categories:	Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Pharmaceutical Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Cycloalkanes
Mol File:	3779-29-1.mol

Diethyl 1,1-cyclobutanedicarboxylate Chemical Properties

Boiling point	104-105 °C12 mm Hg(lit.)
density	1.05 g/mL at 20 °C(lit.)
refractive index	1.4360
Fp	89°C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Dichloromethane, Methanol,
form	Oil
color	Colourless
Specific Gravity	1.05
Water Solubility	Insoluble in water.
BRN	2050195
CAS DataBase Reference	3779-29-1(CAS DataBase Reference)
NIST Chemistry Reference	Diethyl 1,1-cyclobutanedicarboxylate(3779-29-1)
EPA Substance Registry System	1,1-Cyclobutanedicarboxylic acid, diethyl ester (3779-29-1)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Diethyl 1,1-cyclobutanedicarboxylate Usage And Synthesis

Chemical Properties	Colourless Oil
Uses	Diethyl cyclobutane-1,1-dicarboxylate may be used in chemical synthesis studies.
Uses	Diethyl 1,1-cyclobutanedicarboxylate is used as a pharmaceutical intermediate. Used as intermediate in the production of Carboplatin.
Preparation	The preparation of diethyl 1,1-cyclobutanedicarboxylate is as follows:The major product is tetraethy1 1,1,5,5-pentanetetra-carboxylate II with diethyl malonate. To eliminate this side reaction, II was independently prepared by the addition of hydrogen bromide to diethyl allylmalonate (I) and then cyclized to II by treatment with sodium ethylate. The over-all yield from I is about 50%.

Diethyl 1,1-cyclobutanedicarboxylate Preparation Products And Raw materials

Raw materials	4-Bromo-1-butene-->DIETHYL (3-CHLOROPROPYL)MALONATE-->1,3-PROPANEDIOL DI-P-TOLUENESULFONATE-->Diethyl malonate
Preparation Products	(Bromomethyl)cyclobutane-->Cyclobutanemethanol-->TRIMETHYLENE OXIDE-->Pentane-1,1,5,5-tetracarboxylic acid tetraethyl ester-->1-(hydroxymethyl)Cyclobutanecarboxylic acid-->CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER-->DIETHYL 3-BROMOPROPYLMALONATE

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