Ceftriaxone sodium

Ceftriaxone sodium Basic information
Product Name:Ceftriaxone sodium
Synonyms:(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate;Ceftriaxone sodiuM sesquaterhydrate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-;Ceftriaxone SodiuM Trihydrate;Ceftriaxone disodium salt hemiheptahydrate, >=98%;Ceftriaxone (sodium salt hydrate);Ceftriaxone Disodium Salt ;Hemiheptahydrate
CAS:104376-79-6
MF:C18H21N8NaO8S3
MW:596.58
EINECS:626-956-4
Product Categories:VESPRIN;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;API;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity;Ceftriaxone;Heterocycles;Sulfur & Selenium Compounds
Mol File:104376-79-6.mol
Ceftriaxone sodium Structure
Ceftriaxone sodium Chemical Properties
Melting point 236 °C
alpha D25 -165° (c = 1 in water) (calc for water-free substance)
refractive index -160 ° (C=1, H2O)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: soluble50mg/mL
pka~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
form powder or crystals
color White to Off-White
Water Solubility Freely soluble in water
InChIKeyFDRNWTJTHBSPMW-BBJOQENWSA-L
Safety Information
Hazard Codes Xn
Risk Statements 36/37/38-42/43
Safety Statements 26-36-45-37-24-22
WGK Germany 1
RTECS XI0368800
HS Code 29349990
ToxicityLD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)
MSDS Information
ProviderLanguage
SigmaAldrich English
Ceftriaxone sodium Usage And Synthesis
DescriptionCeftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.
Chemical PropertiesWhite Crystalline Solid
UsesAn antibacterial, a third-generation cephalosporin.
UsesA potentially useful antibacterial agent for proteomics research.
Usesantipsychotic
DefinitionChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.
Brand nameRocephin (Roche).
Biological Activityβ -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
Ceftriaxone sodium Preparation Products And Raw materials
3-Desacetyl CefotaxiMe Lactone CEFTRIAXONE SODIUM, USP Cefotaxime sodium Ceftriaxone Sodium intermediate (E)-Ceftriaxone (6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cephalothin sodium CEFTRIAXONE SODIUM E-ISOMER (25 MG) CEFTRIAXONE SODIUM CRUDE Ceftriaxone sodium (solvent crystallization of sterile BPC) CHP 、USP、EP 5kg/tin、2tin/box Ceftriaxone sodium Ceftriaxone sodium crystalline.sterile Ceftriaxone sodium crude,non-sterile,crystalline,sterile Ceftriaxone Sodium sterile USP/EP/JP Ceftriaxone sodium (crude) In-house Spec 25kg/box CEFTRIAXONE IMPURITY A 7-ACT / for Ceftriaxone Sodium Ceftriaxone sodium Non sterile(crude)

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