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| | Phlorizin dihydrate Basic information |
| Product Name: | Phlorizin dihydrate | | Synonyms: | Phlorizin dihydrate
1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE;1-[2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;TIMTEC-BB SBB005924;PHLORETIN-2'-BETA-D-GLUCOSIDE;phloridzin from apple wood;1-[2-(β-d-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone;PHLORIDZIN(RG) | | CAS: | 7061-54-3 | | MF: | C21H26O11 | | MW: | 454.43 | | EINECS: | 628-113-6 | | Product Categories: | Natural Plant Extract | | Mol File: | 7061-54-3.mol |  |
| | Phlorizin dihydrate Chemical Properties |
| Melting point | 113-114 °C(lit.) | | alpha | -52 º (c=3, EtOH) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | neat | | optical activity | [α]20/D 52°, c = 3 in ethanol | | BRN | 66621 | | CAS DataBase Reference | 7061-54-3(CAS DataBase Reference) |
| | Phlorizin dihydrate Usage And Synthesis |
| Uses | Phloridzin dihydrate has been used as:
- a Na+-glucose cotransport inhibitor to test its effect in lowering blood glucose
- a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
- a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity
| | Biochem/physiol Actions | Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin. | | target | NO | PGE | NOS | COX |
| | Phlorizin dihydrate Preparation Products And Raw materials |
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