BOC-NVA-OH

BOC-NVA-OH Basic information

Product Name:	BOC-NVA-OH
Synonyms:	BOC-NORVALINE;BOC-NVA-OH;Boc-NVal-OH;Boc-L-norvaline99%;N-(1-hydroxy-2-oxohexan-3-yl)carbamic acid tert-butyl ester;BOC-NHCH[CH3(CH2)2]-COOH;BOC-L-NORVALINE;BOC-L-NVA-OH
CAS:	53308-95-5
MF:	C10H19NO4
MW:	217.26
EINECS:	1533716-785-6
Product Categories:	Norvaline [Nva];API intermediates;Aliphatics;Amino Acids;Peptide;Carboxylic Acids;Carboxylic Acids
Mol File:	53308-95-5.mol

BOC-NVA-OH Chemical Properties

Melting point	43-47 °C
Boiling point	357.82°C (rough estimate)
density	1.1518 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	Sealed in dry,2-8°C
pka	4.02±0.20(Predicted)
form	powder to crystal
color	White to Light yellow
BRN	3607582

Safety Information

Safety Statements	24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29241990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

BOC-NVA-OH Usage And Synthesis

Chemical Properties	transparent solid
Uses	BOC-L-Norvaline is used in the synthesis of α-amino acid ester prodrugs used as cytotoxic agents against human lung cancer.

BOC-NVA-OH Preparation Products And Raw materials

Raw materials

Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester-->Carbamic acid, N-[(1R)-1-(hydroxymethyl)-2-(phenylsulfonyl)ethyl]-, 1,1-dimethylethyl ester-->L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-phenyl-, methyl ester-->D-Norvaline, N-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester-->(2R)-2-BOC-AMINO-3-PHENYLSULFONYL-1-(2-TETRAHYDROPYRANYLOXY)PROPANE, 98-->BOC-SER(TOS)-OCH3-->Boc-L-serine methyl ester-->Di-tert-butyl dicarbonate-->L-Norvaline-->2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Preparation Products

N-BOC-L-NORVALINE ETHYL ESTER

BOC-PYR-OH DCHA BOC-CHA-OH DCHA BOC-LEU-ONP BOC-L-Proline BOC-NVA-OH Boc-L-Glutamic acid BOC-GLU(OBZL)-ONP N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester BOC-LEU-OSU BOC-LYS(Z)(ISOPROPYL)-OH BOC-GLU(OME)-OH DCHA BOC-LYS(Z)-OH DCHA BOC-PRO-ONP BOC-HYP(BZL)-OH BOC-LYS(Z)-OSU N-tert-Butoxycarbonyl-N'-benzyloxycarbonyl-L-ornithine BOC-PRO-OSU N-alpha-(tert-Butoxycarbonyl)-L-lysine

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