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| | 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Basic information |
| Product Name: | 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE | | Synonyms: | VAN BOOM'S REAGENT;SALICYLCHLOROPHOSPHITE;2-CHLORO-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE;2-CHLORO-4H-1,2,3-BENZODIOXAPHOSPHORIN-4-ONE;2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE;2-chloro-1,3,2-benzodioxaphosphonic heterocyclohexane-4-one;ChloroHbenzodioxaphosphorinone;2-Chloro-4H-1,2,3-benzodioxaphosphorin-4-one 90% | | CAS: | 5381-99-7 | | MF: | C7H4ClO3P | | MW: | 202.53 | | EINECS: | | | Product Categories: | Phospholipids - 13C & 2H;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Phosphorylation;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Phosphorylating and Phosphitylating Agents | | Mol File: | 5381-99-7.mol |  |
| | 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Chemical Properties |
| Melting point | 36-40 °C (lit.) | | Boiling point | 127-128 °C/11 mmHg (lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide. | | form | solid | | color | White or Colorless to Orange to Green | | BRN | 1311951 | | Stability: | Water Sensitive | | CAS DataBase Reference | 5381-99-7(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 14-34-37 | | Safety Statements | 26-36/37/39-43-45 | | RIDADR | UN 3261 8/PG 1 | | WGK Germany | 3 | | F | 3-10 | | Hazard Note | Corrosive | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29349990 |
| | 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog. | | Uses | 2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:
- In the phosphorylation and phosphitylation of alcohols.
- In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
- To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.
| | Uses | Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs |
| | 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Preparation Products And Raw materials |
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